分析丁苯酞氯化钠注射液在急性缺血性脑卒中患者中的疗效及保护机制  

Effect and protective mechanism of butylphthalide and sodium chloride injection in patients with acute ischemic stroke

作　　者：李君[1] 张冠群[1] 刘君[1] 朱亮[1] 王江波[1] 张宁[1] 刘涣 LI Jun;ZHANG Guan-qun;LIU Jun(Department of Nerve Medicine,Xuzhou Central Hospital,Xuzhou 221009,China)

机构地区：[1]徐州市中心医院神经内科,221009

出　　处：《中国实用医药》2020年第36期20-22,共3页China Practical Medicine

摘　　要：目的探讨丁苯酞氯化钠注射液在急性缺血性脑卒中患者中的治疗效果及保护机制。方法68例急性缺血性脑卒中患者,随机分成对照组和实验组,每组34例。对照组患者采用常规综合方法治疗,实验组患者在常规治疗的基础上加用丁苯酞氯化钠注射液治疗。对比两组患者的临床疗效,血清中的超氧化物歧化酶(SOD)、丙二醛(MDA)水平,Barthel指数(BI)、神经功能缺损评分标准(CSS)评分及不良反应发生情况。结果治疗后,实验组患者的SOD(99.22±10.04)U/ml高于对照组的(87.51±9.21)U/ml,MDA(4.55±0.71)nmol/ml低于对照组的(6.15±0.92)nmol/ml,差异具有统计学意义(P<0.05)。治疗后,实验组患者的CSS评分(17.81±4.26)分、BI评分(59.29±9.03)分优于对照组的(24.39±5.75)、(46.59±9.14)分,差异统计学意义(P<0.05)。实验组患者的临床治疗总有效率97.1%显著高于对照组的82.4%,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论在急性缺血性脑卒中患者的临床治疗过程中,采用丁苯酞氯化钠注射液治疗的效果十分显著,可减少患者治疗中的不良反应,且对患者具有一定的保护作用,值得在临床上推广。Objective To discuss the therapeutic effect and protective mechanism of butylphthalide and sodium chloride injection in patients with acute ischemic stroke.Methods A total of 68 patients with acute ischemic stroke were randomly divided into control group and experimental group,with 34 cases in each group.The control group received conventional comprehensive treatment,and the experimental group received butylphthalide sodium chloride injection on the basis of conventional treatment.The clinical efficacy,serum superoxide dismutase(SOD),malondialdehyde(MDA),Barthel index(BI),China stroke scale(CSS)scores and occurrence of adverse reactions were compared between the two groups.Results After treatment,SOD(99.22±10.04)U/ml of the experimental group was higher than(87.51±9.21)U/ml of the control group,and MDA(4.55±0.71)nmol/ml was lower than(6.15±0.92)nmol/ml of the control group,and the difference was statistically significant(P<0.05).After treatment,CSS score(17.81±4.26)points and BI score(59.29±9.03)points of the experimental group were better than(24.39±5.75)and(46.59±9.14)points of the control group,and the difference was statistically significant(P<0.05).The total effective rate of clinical treatment of the experimental group was 97.1%,which was significantly higher than 82.4%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference between the two groups(P>0.05).Conclusion Butylphthalide and sodium chloride injection has remarkable effect in clinical treatment of acute ischemic stroke,and has a certain protective effect,which is worth popularizing in clinic.

关 键 词：丁苯酞氯化钠注射液 急性缺血性脑卒中 临床效果 保护机制 

分 类 号：R743.3[医药卫生—神经病学与精神病学]