盐酸羟考酮缓释片与盐酸曲马多缓释片治疗癌痛的有效性对照  

Comparison of the efficacy of oxycodone hydrochloride prolonged-release tablets and tramadol hydrochloride sustained-release tablets in the treatment of cancer pain

作　　者：刘正红 LIU Zheng-hong(Department of Medicine and Equipment,Benxi Third People's Hospital,Benxi 117022,China)

机构地区：[1]辽宁省本溪市第三人民医院药械科,117022

出　　处：《中国实用医药》2020年第35期112-114,共3页China Practical Medicine

摘　　要：目的研究盐酸羟考酮缓释片与盐酸曲马多缓释片治疗癌痛的有效性。方法 68例在肿瘤科治疗的癌痛患者,采用随机数字表法分为对照组和观察组,每组34例。对照组患者采用盐酸曲马多缓释片治疗,观察组患者采用盐酸羟考酮缓释片治疗。比较两组治疗后疼痛缓解率及两组治疗前后视觉模拟评分和便秘发生率。结果治疗后,观察组的疼痛缓解率85.29%(29/34)高于对照组的52.94%(18/34),差异有统计学意义(χ^(2)=8.34, P<0.05)。治疗后,两组患者的视觉模拟评分均低于治疗前,且观察组(2.53±0.24)分低于对照组的(4.25±1.12)分,差异有统计学意义(P<0.05)。观察组患者的便秘发生率5.88%(2/34)低于对照组的29.41%(10/34),差异有统计学意义(P<0.05)。结论采用盐酸羟考酮缓释片用于癌痛患者可获得较为满意的效果,对患者的疼痛缓解有积极的作用,且不良反应较少,值得推广应用。Objective To study the efficacy of oxycodone hydrochloride prolonged-release tablets and tramadol hydrochloride sustained-release tablets in the treatment of cancer pain.Methods A total of 68 cancer pain patients were divided into control group and observation group according to random numerical table,with 34 cases in each group.The control group was treated with tramadol hydrochloride sustained-release tablets,and the observation group was treated with oxycodone hydrochloride prolonged-release tablets.The pain remission rate after treatment,visual analogue scale score before and after treatment and incidence of constipation were compared between the two groups.Results After treatment,the pain remission rate 85.29%(29/34)of the observation group was higher than 52.94%(18/34)of the control group,and the difference was statistically significant(χ^(2)=8.34,P<0.05).After treatment,the visual analogue scale score of the two groups were lower than those before treatment,and the observation group(2.53±0.24)points was lower than(4.25±1.12)points of the control group,and the difference was statistically significant(P<0.05).The incidence of constipation 5.88%(2/34)of the observation group was lower than 29.41%(10/34)of the control group,and the difference was statistically significant(P<0.05).Conclusion The application of oxycodone hydrochloride prolonged-release tablets can obtain a relatively satisfactory effect for cancer pain patients with fewer adverse reactions,and has a positive effect on the pain relief of patients.It is worthy of promotion and application.

关 键 词：盐酸羟考酮缓释片 盐酸曲马多缓释片 癌痛 有效性 

分 类 号：R730.5[医药卫生—肿瘤]