血清TN-C、Irisin与急性缺血性脑卒中患者病情严重程度和预后的关系  

Relationship between serum TN-C,Irisin and the severity and prognosis of patients with acute ischemic stroke

作　　者：张海柳 杨国涛[1] 李聪慧 王文慧 王春雨 董爱勤[1] 王芳[1] ZHANG Hailiu;YANG Guotao;LI Conghui(Third Department of Neurology,Cangzhou Central Hospital,Cangzhou,Hebei 061000,China)

机构地区：[1]沧州市中心医院神经内三科,河北沧州061000

出　　处：《中风与神经疾病杂志》2020年第12期1080-1083,共4页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨血清腱糖蛋白C(TN-C)、鸢尾素(Irisin)与急性缺血性脑卒中(AIS)患者病情严重程度和预后的关系。方法选取203例AIS患者为AIS组,根据美国国立卫生研究院卒中量表(NIHSS)分与改良Rankin量表(mRS)分为重度组(n=52)、中度组(n=87)、轻度组(n=64)和预后良好组(n=125)、预后不良组(n=78);另选取74名同时期体检健康者为对照组,对比各组血清TN-C、Irisin水平,Pearson相关性分析血清TN-C、Irisin水平与NIHSS、mRS评分的相关性,ROC曲线分析血清TN-C、Irisin水平预测AIS预后价值。结果AIS组血清TN-C水平明显高于对照组,Irisin水平明显低于对照组(P<0.05);重度组血清TN-C水平明显高于中度组,Irisin水平明显低于中度组(P<0.05);中度组血清TN-C水平明显高于轻度组,Irisin水平明显低于轻度组(P<0.05);预后不良组血清TN-C水平明显高于预后良好组,Irisin水平明显低于预后良好组(P<0.05);Pearson相关性分析显示,AIS组血清TN-C水平与NIHSS、mRS评分呈正相关(P<0.05);血清Irisin水平与NIHSS、mRS评分呈负相关(P<0.05);ROC曲线显示,TN-C+Irisin预测AIS预后的AUC、敏感度、特异度均高于TN-C、Irisin单独预测。结论升高的血清TN-C水平及降低的Irisin水平能反应AIS患者病情严重程度及不良预后,二者联合测定能提升对AIS患者预后的预测价值,可作为评估预后的指标。Objective To explore the relationship between serum tenascin C(TN-C),irisin(Irisin)and the severity and prognosis of patients with acute ischemic stroke(AIS).Methods 203 AIS patients admitted to our hospital(January 2017 to December 2019)were selected as the AIS group.According to the National Institutes of Health Stroke Scale(NIHSS)and Modified Rankin Scale(mRS),they were divided into severe group(n=52),moderate group(n=87),mild group(n=64)good prognosis group(n=125)and poor prognosis group(n=78),another 74 healthy people at the same period were selected as the control group,and the serum TN-C and Irisin level were compared between the groups,Pearson correlation analysis was used to analyze the correlation between serum TN-C and Irisin levels and NIHSS,mRS scores,ROC curve analysis was used to analyze the prognostic value of serum TN-C and Irisin levels in AIS.Results The serum TN-C levels in the AIS group were significantly higher than those in the control group,and the Irisin levels were significantly lower than those in the control group(P<0.05);the serum TN-C levels in the severe group were significantly higher than those in the moderate group,and the Irisin levels were significantly lower than those in the moderate group(P<0.05);the serum TN-C levels in the moderate group were significantly higher than those in the mild group,and the Irisin levels were significantly lower than those in the mild group(P<0.05);the serum TN-C levels in the poor prognosis group were significantly higher than those in the good prognosis group,Irisin levels were significantly lower than those in the good prognosis group(P<0.05);pearson correlation analysis showed that the serum TN-C level in the AIS group was positively correlated with NIHSS and mRS scores(P<0.05);the serum Irisin level was negatively correlated with NIHSS and mRS scores(P<0.05);ROC curve showed that the AUC,sensitivity and specificity of TN-C+Irisin predicting the prognosis of AIS were higher than those predicted by TN-C and Irisin alone.Conclusion Elevated seru

关 键 词：急性缺血性脑卒 腱糖蛋白C 鸢尾素 严重程度 预后 

分 类 号：R743.3[医药卫生—神经病学与精神病学]