基于直线加速器的分次立体定向放疗在脑寡转移肿瘤中的应用  

Application of linac-based fractionated stereotactic radiation therapy in treatment of oligo brain metastases

作　　者：周冲[1] 郭汝元[2] 夏铀铀 练炼[4] 殷海涛[1] Zhou Chong;Guo Ruyuan;Xia Youyou;Lian Lian;Yin Haitao(Department of Radiotherapy,Xuzhou Central Hospital in Jiangsu Province,Xuzhou 221009,China;Department of Head and Neck Radiotherapy,Shanxi Provincial Cancer Hospital,Taiyuan 030013,China;Department of Radiotherapy,Lianyungang Hospital,Xuzhou Medical University,Lianyungang 222061,China;Department of Oncology,Suzhou Xiangcheng People's Hospital in Jiangsu Province,Suzhou 215131,China)

机构地区：[1]江苏省徐州市中心医院放疗科,221009 [2]山西省肿瘤医院放疗头颈综合病区,太原030013 [3]徐州医科大学附属连云港医院放疗科,222061 [4]江苏省苏州市相城人民医院肿瘤科,215131

出　　处：《肿瘤研究与临床》2020年第11期741-744,共4页Cancer Research and Clinic

基　　金：国家自然科学基金(81672973);江苏省青年医学重点人才课题(QNRC2016498);徐州市临床技术骨干研究计划(2019GG004)。

摘　　要：肿瘤患者容易发生脑转移,立体定向放射外科(SRS)是脑寡转移肿瘤有效的治疗手段。然而,SRS对于体积较大的转移病灶并不适宜。分次立体定向放疗(FSRT)是一种较新的治疗脑转移瘤的技术手段,能在给予转移病灶较高照射剂量的同时尽可能保护照射野之外的正常组织及器官,且治疗后脑转移病灶局部控制率良好。文章对不同分割方案FSRT的剂量效应关系、不良反应以及FSRT与靶向治疗、免疫治疗联合应用的进展进行介绍。Brain metastases are common in oncologic patients.Stereotactic radiosurgery(SRS)is an effective treatment for oligo brain metastases.However,SRS is not suitable for large metastatic lesions.Fractionated stereotactic radiation therapy(FSRT)is a new option for the treatment of brain metastases.It can deliver high doses of radiation to tumor while protecting the normal tissues and organs outside the irradiation field as much as possible and maintaining good local control rate of tumors.This article reviews the dose-response relationship and adverse reactions of FSRT with different fractionated dose schemes,and the progress of FSRT combined with targeted therapy and immunotherapy.

关 键 词：肿瘤 分子靶向治疗 免疫疗法 分次立体定向放射治疗 

分 类 号：R739.41[医药卫生—肿瘤] R730.55[医药卫生—临床医学]