抗肿瘤化疗影响机体免疫功能的研究进展  

Advances in antitumor chemotherapy effects on immune function

作　　者：梁欣妍 黄迪[1,2] LIANG XinYan;HUANG Di(Breast Tumor Center,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou 510120,China;Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou 510120,China)

机构地区：[1]中山大学孙逸仙纪念医院乳腺肿瘤中心,广州510120 [2]中山大学孙逸仙纪念医院,广东省恶性肿瘤表观遗传与基因调控重点实验室,广州510120

出　　处：《中国科学：生命科学》2020年第10期1068-1081,共14页Scientia Sinica(Vitae)

基　　金：国家自然科学基金(批准号:81802643);广东省自然科学基金(批准号:2018A030310085);逸仙科研启航项目(批准号:YXQH201813)资助。

摘　　要：化疗是肿瘤常规的治疗手段,化疗杀伤肿瘤细胞的同时,也对免疫系统产生了抑制作用.近年来多项研究发现,化疗也能激活机体的免疫功能,具有双向作用.本文梳理了肿瘤治疗过程中化疗对肿瘤免疫的影响,并探索了将化疗和机体免疫结合的治疗方案.评估化疗后机体免疫的不同变化,调整化疗方案或联合使用免疫治疗,可为临床提供更好的治疗策略,提高肿瘤的治疗效果.Chemotherapy has become one of the most conventional treatments for cancer,but it may damage the immune system while killing tumor cells.In recent years,however,studies have indicated that chemotherapy has a biphasic effect on tumor immunity by activating immune function.This review summarizes the effect of chemotherapy on the immune system during the treatment of cancer patients and explores better therapeutic strategies to improve treatments and reduce side effects by adjusting the regimens or combining chemotherapy with immunotherapy depending on the changes of immunity after chemotherapy.

关 键 词：化疗 免疫系统 免疫抑制 免疫激活 抗肿瘤免疫 

分 类 号：R730.53[医药卫生—肿瘤]