胸苷酸合成酶与肿瘤  

Thymidylate synthase and tumor

作　　者：黄志国 胡孔旺[1] Huang Zhiguo;Hu Kongwang(Department of General Gastrointestinal Surgery,First Affiliated Hospital of Anhui Medical University,Hefei 230022,China)

机构地区：[1]安徽医科大学第一附属医院普外科胃肠外科,合肥230022

出　　处：《国际肿瘤学杂志》2020年第10期615-618,共4页Journal of International Oncology

基　　金：安徽省省级质量工程项目(2017jyxm1073);吴阶平医学基金会临床科研专项资助基金(320.6750.19092-19);安徽省科技厅重点研究与开发计划项目(202004j0702003)。

摘　　要：胸苷酸合成酶(TS)是DNA合成中的关键酶,常常作为化疗药物作用靶点。TS在多种肿瘤(如非小细胞肺癌、结直肠癌、乳腺癌等)中的表达与患者的临床预后及化疗药物耐药密切相关。通过各种分子机制降低肿瘤组织中TS的表达成为提高化疗疗效及改善临床预后的重要手段。Thymidylate synthase(TS)is a key enzyme in DNA synthesis and is often used as a target for chemotherapy drugs.In a variety of tumors such as non-small cell lung cancer,colorectal cancer,breast cancer,etc,the expression of TS is closely related to the clinical prognosis and chemotherapy drug resistance of patients.Reducing the expression of TS in tumor tissues through various molecular mechanisms has become an important means to improve the efficacy of chemotherapy drugs and improve the clinical prognosis.

关 键 词：肿瘤 抗药性 胸苷酸合酶 

分 类 号：R730.2[医药卫生—肿瘤]