双歧杆菌三联活菌散联合美沙拉嗪治疗轻、中度活动期溃疡性结肠炎患者的临床疗效和安全性  

Clinical Efficacy and Safety of Bifidobacterium Sanlian Huojun Powder Combined with Mesalazine in the Treatment of Mild,Moderate Active Patients with Ulcerative Colitis

作　　者：李倩[1] 田丰[1] LI Qian;TIAN Feng(The First Department of Gastroenterology,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院消化内科,沈阳110004

出　　处：《中国药物经济学》2020年第11期85-87,91,共4页China Journal of Pharmaceutical Economics

摘　　要：目的探讨双歧杆菌三联活菌散联合美沙拉嗪治疗轻、中度活动期溃疡性结肠炎患者的临床疗效和安全性。方法选取中国医科大学附属盛京医院2017年5月至2019年5月收治的84例溃疡性结肠炎患者作为研究对象,按照随机数字表法分为观察组与对照组,各42例。两组患者给予美沙拉嗪肠溶片口服,观察组患者加用双歧杆菌三联活菌散治疗,比较两组患者免疫功能相关指标、治疗效果以及不良反应发生情况。结果两组患者治疗前Ig A、Ig G、Ig M、白细胞介素-17(IL-17)、白细胞介素-23(IL-23)、肿瘤坏死因子-α(TNF-α)水平比较,差异无统计学意义(P>0.05);治疗后,两组患者IgA、IgG、IL-17、IL-23、TNF-α水平明显下降,且观察组IgA、IgG、IL-17、IL-23、TNF-α水平低于对照组,差异有统计学意义(P<0.05)。观察组患者治疗有效率为95.2%,明显高于对照组的76.2%,差异有统计学意义(P<0.05)。两组患者未出现明显的不良反应,观察组与对照组均有2例患者出现食欲减退,未经处置消失,无中途退出研究者,两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论双歧杆菌三联活菌散联合美沙拉嗪治疗轻、中度活动期溃疡性结肠炎患者,有助于恢复肠道菌群平衡,改善免疫功能相关指标,疗效确切,且安全性好。Objective To investigate the clinical efficacy and safety of perfiecon combined with mesalazine in patients with mild to moderate active ulcerative colitis.Methods A total of 84 patients with ulcerative colitis admitted to Shengjing Hospital of China Medical University from May 2017 to May 2019 were selected as the research objects and were assigned into an observation group and a control group according to the random number table method,with 42 cases in each group.The 2 groups of patients were given mesalazine enteric-coated tablets orally,patients in the observation group were treated with oral enteric-coated tablets plus bifidobacterium triple live bacteria powder for the treatment.The indexes of immune function,therapeutic effect and adverse reactions of the 2 groups were compared.Results There was no significant difference in IgA,IgG,IgM,IL-17,IL-23,TNF-αbetween the 2 groups before treatment,the difference was not statistically significant(P>0.05).After treatment,IgA,IgG,IL-17,IL-23 and TNF-αlevels in both groups significantly decreased.And the levels of IgA,IgG,IL-17,IL-23 and TNF-αin the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The effective rate of treatment in the observation group was 95.2%,which was significantly higher than the 76.2%in the control group.The difference was statistically significant(P<0.05).There were no obvious adverse reactions in the 2 groups of patients.There was no significant difference in 2 patients in the observation group and the control group who experienced loss of appetite,disappearance without treatment,and no one withdrew from the study(P>0.05).Conclusion Bifidobacterium Sanlian Huojun Powder combined with mesalazine in the treatment of patients with mild to moderately active ulcerative colitis can help restore the balance of intestinal flora,improve immune function-related indicators,and have definite curative effects and good safety.

关 键 词：双歧杆菌三联活菌散 美沙拉嗪 溃疡性结肠炎 

分 类 号：R574.62[医药卫生—消化系统] R975[医药卫生—内科学]