边缘性人格障碍患者杏仁核和前额叶与全脑的功能连接特征  

Whole-brain Functional Connectivity of Amygdala and Prefrontal Cortex in Patients with Borderline Personality Disorder

作　　者：曹万依 廖海燕[2] 蔡赛男[2] 彭婉蓉 刘朝霞 谭长连[2] 蚁金瑶[1] CAO Wan-yi;LIAO Hai-yan;CAI Sai-nan;PENG Wan-rong;LIU Zhao-xia;TAN Chang-lian;YI Jin-yao(Medical Psychological Center,The Second Xiangya Hospital,Central South University,Changsha 410011,China;Department of Radiology,The Second Xiangya Hospital,Central South University,Changsha 410011,China)

机构地区：[1]中南大学湘雅二医院医学心理中心,长沙410011 [2]中南大学湘雅二医院放射科,长沙410011

出　　处：《中国临床心理学杂志》2020年第6期1077-1082,共6页Chinese Journal of Clinical Psychology

基　　金：国家自然科学基金(81370034)。

摘　　要：目的:分析边缘性人格障碍(Borderline Personality Disorder,BPD)患者情绪加工的核心脑区(杏仁核和背外侧前额叶)与全脑的功能连接特征。方法:35名BPD患者(19男,16女)和36名健康对照组被试(16男,20女)完成系列心理评估量表与静息态功能磁共振成像扫描,以双侧杏仁核和双侧背外侧前额叶为感兴趣区,分析其与全脑的功能连接。采用偏相关分析检验差异脑区连接值与心理特征指标之间的关系。结果:与健康对照组相比,BPD患者左侧杏仁核与左侧脑岛和右侧额下回的功能连接减弱。左侧背外侧前额叶与左侧楔前叶和左侧枕中回、右侧背外侧前额叶与右侧脑岛的功能连接也均较对照组减弱。BPD患者组左侧杏仁核与右侧额下回的功能连接强度与消极认知性情绪调节得分呈显著负相关。结论:BPD患者杏仁核及背外侧前额叶的静息态功能连接存在异常,这为阐明BPD情绪失调的神经病理学机制提供了新的实验依据。Objective:To investigate the functional connectivity(FC)of two core emotion-related brain regions(amygda⁃la;dorsolateral prefrontal cortex,dlPFC)with the whole brain in patients with borderline personality disorder(BPD).Meth⁃ods:A series of psychological assessments and resting-state functional magnetic resonance imaging scanning were conduct⁃ed in 35 BPD patients(19 males)and 36 healthy controls(16 males).The amygdala and dlPFC were defined as seeds in the whole-brain FC analysis.Partial correlation was used to analyze the association between FC values and psychological vari⁃ables.Results:Compared with healthy controls,BPD patients showed decreased FC of left amygdala with left insula and right inferior frontal gyrus,left dlPFC with left precuneus and left middle occipital gyrus,and right dlPFC with right insula.The FC between left amygdala and right inferior frontal gyrus was negatively correlated with the scores of negative emotion regulation subscale in BPD patients.Conclusion:Both the amygdala and dlPFC have abnormal FC with other brain re⁃gions,which may contribute to the emotional dysregulation in BPD.

关 键 词：边缘性人格障碍 杏仁核 背外侧前额叶 神经影像学 

分 类 号：R395.1[哲学宗教—心理学]