玻璃体内注射曲安奈德联合玻璃体切除术治疗糖尿病性黄斑水肿的临床疗效  

Clinical Effect of Intravitreal Injection of Triamcinolone Acetonide Combined with Vitrectomy in the Treatment of Diabetic Macular Edema

作　　者：张荟[1] 刘洋[1] ZHANG Hui;LIU Yang(Department of Ophthalmology,Nanjing Hospital Affiliated to Nanjing Medical University(Nanjing First Hospital),Nanjing,Jiangsu Province,210029 China)

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)眼科,江苏南京210029

出　　处：《系统医学》2020年第23期4-7,共4页Systems Medicine

摘　　要：目的探析糖尿病性黄斑水肿患者接受玻璃体内注射曲安奈德联合玻璃体切除术治疗的临床疗效。方法研究对象来自该院2017年1月—2019年12月收治的增生性糖尿病性视网膜病变(PDR)糖尿病性黄斑水肿患者,以患者入院顺序为依据,分成对照组(43例)与观察组(43例)。对照组患者实施玻璃体切除术,观察组患者基于对照组玻璃体切除术,于玻璃体内注射曲安奈德。对比两组患者最佳矫正视力(BCVA)、眼压及黄斑中心凹厚度值(CMT)情况。结果两组治疗前BCVA对比,差异无统计学意义(t=0.515,P>0.05);治疗后3个月观察组BCVA(0.224±0.732)与对照组(0.181±0.594)对比,观察组明显优于对照组,差异有统计学意义(t=4.077,P<0.05);治疗后3个月观察组与对照组BCVA均优于治疗前,差异有统计学意义(t=6.773、5.084,P<0.05)。观察组与对照组治疗前眼压比较,差异无统计学意义(t=0.355,P>0.05);观察组治疗后1、3个月眼压分别为(17.23±7.01)、(14.35±3.52)mmHg,明显优于治疗前,差异有统计学意义(t=6.771、5.414,P<0.05)。观察组治疗后3个月CMT(224±32)μm低于对照组的(241±44)μm,差异有统计学意义(t=2.049,P<0.05)。结论糖尿病性黄斑水肿患者接受玻璃体切除术,通过曲安奈德注射在患者玻璃体内的辅助作用,达到了理想的诊治效果,临床治疗安全性较高,但其远期疗效与安全性有待进一步证实。Objective To explore the clinical efficacy of intravitreal injection of triamcinolone acetonide combined with vitrectomy in patients with diabetic macular edema.Methods The research subjects were patients with proliferative diabetic retinopathy(PDR)diabetic macular edema who were admitted to the hospital from January 2017 to December 2019.Based on the order of admission,they were divided into a control group(43 cases)and an observation group(43 cases),of which the patients in the control group underwent vitrectomy;the patients in the observation group received triamcinolone acetonide intravitreal injection based on the vitrectomy in the control group.The best corrected visual acuity(BCVA),intraocular pressure and foveal thickness(CMT)of the two groups were compared.Results There was not significant difference in BCVA between the two groups before treatment(t=0.515,P>0.05);Three months after treatment,the observation group BCVA(0.224±0.732)was compared with the control group(0.181±0.594),the observation group was significantly better than the control group,the difference was statistically significant(t=4.077,P<0.05);Three months after treatment,the BCVA of the observation group and the control group were better than those before treatment,and the difference was statistically statistically significant(t=6.773,5.084,P<0.05).There was not significant difference in intraocular pressure between the observation group and the control group before treatment(t=0.355,P>0.05);The intraocular pressures of the observation group were(17.23±7.01)and(14.35±3.52)mmHg at 1 and 3 months after treatment,which were significantly better than those before treatment,and the difference was statistically significant(t=6.771,5.414,P<0.05).The CMT(224±32)μm of the observation group was lower than that of the control group(241±44)μm 3 months after treatment,the difference was statistically significant(t=2.049,P<0.05).Conclusion Patients with diabetic macular edema underwent vitrectomy,through the auxiliary effect of triamcinolone acet

关 键 词：糖尿病 曲安奈德 玻璃体切除术 黄斑水肿 

分 类 号：R77[医药卫生—眼科]