口腔扁平苔藓相关microRNAs的研究进展  

Research progress on microRNAs connected with oral lichen planus

作　　者：潘英潇 郭大伟[2] 李新[1] 卢恕来[2] PAN Yingxiao;GUO Dawei;LI Xin(LU Shulai2.1.School of Stomatology of Qingdao University,Qingdao 266011,China;Department of Stomatology,Affiliated Qingdao Municipal Hospital,Qingdao University,Qingdao 266011,China)

机构地区：[1]青岛大学口腔医学院,山东青岛266011 [2]青岛大学附属青岛市市立医院口腔医疗中心,山东青岛266011

出　　处：《口腔疾病防治》2021年第3期206-210,共5页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：山东省医药卫生科技发展计划项目面上项目(20⁃15WS0327);山东省卫计委中医药科技发展计划项目(2015⁃378);青岛市科技计划项目(17⁃3⁃3⁃39⁃nsh)。

摘　　要：口腔扁平苔藓(oral lichen planus,OLP)是一种常见的病因不明的慢性炎症性疾病,细胞介导的局部免疫应答紊乱在其中发挥着重要作用。目前发现microRNAs(miRNAs)在炎性反应、自身免疫性疾病的发生发展中起到重要作用,已有大量研究报道显示miRNAs可能与OLP相关。文献复习结果表明,miRNA⁃19a高表达和miRNA⁃122、miRNA⁃199、miRNA⁃138、miRNA⁃635、miRNA⁃578低表达可能通过调控白介素、干扰素、肿瘤坏死因子等细胞因子而与OLP的发生相关;miRNA⁃125a低表达和miRNA⁃132、miRNA⁃146a、miRNA⁃155高表达可能通过影响CD4^+T细胞在Th1/Th2亚群上的分化过程而与OLP的严重程度相关;miRNA⁃26a、miRNA⁃29a、miRNA⁃31高表达和miRNA⁃27b、miRNA⁃200a、miRNA⁃137低表达可能通过具有功能关系的相关基因组、转录因子和miRNA协同调控网络等与OLP癌变风险相关。目前研究仍存在不足之处,许多利用基因芯片筛选差异表达miRNA的研究并没有根据OLP类型或癌变风险进一步的分组探究。Oral lichen planus(OLP)is a common chronic inflammatory disease with unclear etiology,in which disor⁃der of the cell⁃mediated local immune response plays an important role.MicroRNAs(miRNAs)have been found to play an important role in the occurrence and development of inflammatory responses and autoimmune diseases.In recent years,many studies have reported that miRNAs may be related to OLP.According to a literature review,high expres⁃sion of miRNA⁃19a and low expression of miRNA⁃122,miRNA⁃199,miRNA⁃138,miRNA⁃635 and miRNA⁃578 may be related to the occurrence of OLP by regulating cytokines such as interleukin,interferon and tumor necrosis factor.The low expression of miRNA⁃125a and the high expression of miRNA⁃132,miRNA⁃146a and miRNA⁃155 may be related to the severity of OLP by influencing the differentiation of CD4^+T cells in the Th1/Th2 subgroup.High expression of miRNA⁃26a,miRNA⁃29a and miRNA⁃31 and low expression of miRNA⁃27b,miRNA⁃200a and miRNA⁃137 may be as⁃sociated with malignant risk of OLP through functionally related genomes,transcription factors and miRNA coregulatory networks.Some deficiencies remain in current studies.For example,many studies using microarrays to screen differen⁃tially expressed miRNAs have not been further grouped according to the type of OLP or cancer risk.

关 键 词：口腔扁平苔藓 非编码RNA MICRORNAS 发病机制 疾病严重程度 癌变风险 癌基因 抑癌基因 

分 类 号：R78[医药卫生—口腔医学]