丹红注射液联合丁苯酞治疗老年脑梗死的临床疗效  

Clinical efficacy of Danhong injection combined with butylphthalide in the treatment of senile cerebral infarction

作　　者：田志强 柯桂兰 TIAN Zhi-qiang;KE Gui-lan(Traditional Chinese Medicine of Jiangxia District of Wuhan City,Wuhan 430200,China)

机构地区：[1]湖北省武汉市江夏区中医医院,430200

出　　处：《临床合理用药杂志》2020年第33期4-6,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨丹红注射液联合丁苯酞治疗老年脑梗死的临床疗效。方法选取武汉市江夏区中医医院2017年7月—2018年12月收治的老年脑梗死患者162例,按照随机数字表法分为对照组与观察组,各81例。对照组予以丁苯酞治疗,观察组在对照组基础上予以丹红注射液治疗。比较2组临床疗效,治疗前及治疗3、7、14 d血液流变学指标(全血低切黏度、全血高切黏度、血浆黏度、血细胞比容及纤维蛋白原)、血清炎性因子〔白介素6(IL-6)、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)〕,并观察2组不良反应发生情况。结果观察组临床疗效优于对照组(P<0.05)。治疗前2组全血低切黏度、全血高切黏度、血浆黏度、血细胞比容、纤维蛋白原、IL-6、TNF-α、CRP比较,差异无统计学意义(P>0.05);治疗3、7、14 d后观察组全血低切黏度、血浆黏度、纤维蛋白原、IL-6、TNF-α、CRP低于对照组(P<0.05);治疗7、14 d后观察组全血高切黏度、血细胞比容低于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论丹红注射液联合丁苯酞治疗老年脑梗死的临床疗效确切,可有效改善患者血液流变学水平,降低炎性程度,且安全性较高。Objective To observation the Clinical efficacy of Danhong injection combined with butylphthalide in the treatment of senile cerebral infarction.Methods A total of 162 cases of patients with senile cerebral infarction were selected from July 2017 to December 2018 in Traditional Chinese Medicine of Jiangxia District of Wuhan City,which were randomly divided into control group and observation group,81 cases in each group.The control group was treated with butylphthalide,and the observation group was treated with Danhong injection on the basis of the control group.Clinical efficacy,hemorheological indexes(whole blood low shear viscosity,whole blood high shear viscosity,plasma viscosity,hematocrit and fibrinogen) before treatment and 3,7 and 14 days of treatment serum inflammatory factors(IL-6,TNF-α,CRP)were compared between the two groups,and the incidence of adverse reactions were observed.Results The clinical efficacy of the observation group was better control group(P<0.05).Before treatment,there was no significant difference in whole blood low shear viscosity,whole blood high shear viscosity,plasma viscosity,hematocrit and fibrinogen,IL-6,TNF-α and CRP between the two groups(P>0.05);after 3,7 and 14 days of treatment,the whole blood low shear viscosity,plasma viscosity,fibrinogen,IL-6,TNF-α and CRP in the observation group were lower than control group(P<0.05);after 7 and 14 days of treatment,the whole blood high shear viscosity and hematocrit in the observation group were lower than control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Danhong injection combined with butylphthalide have an exact clinical effect for senile cerebral infarction,which can effectively improve the hemorheological level of patients and reduce the inflammatory degree,and with high safety.

关 键 词：脑梗死 老年人 丹红注射液 丁苯酞 血液流变学 治疗结果 血清炎性因子 

分 类 号：R743.33[医药卫生—神经病学与精神病学]