射频消融术联合宫瘤消胶囊治疗子宫肌瘤的临床效果  

Clinical Analysis of Radiofrequency Ablation Combined with Gongliuxiao Capsule in the Treatment of Uterine Myoma

作　　者：吴蕾 古航 朱莉华 原继荣 邵雨 Wu Lei;Gu Hang;Zhu Lihua;Yuan Jirong;Shao Yu(Department of Obstetrics and Gynecology,Rici Women’s and Children’s Hospital,Shanghai 200040,China;不详)

机构地区：[1]上海瑞慈水仙妇儿医院妇产科,上海市200040 [2]上海长海医院妇产科,上海市200433 [3]复旦大学附属妇产科医院妇科,上海市200021

出　　处：《中国病案》2020年第11期101-104,共4页Chinese Medical Record

摘　　要：目的探讨射频消融术联合宫瘤消胶囊治疗子宫肌瘤的临床效果。方法选取2013年6月1日-2017年6月30日某院收治的子宫肌瘤患者486例,采用随机数字表法将患者分为对照组(n=243)和观察组(n=243)。对照组采用经腹部超声引导射频消融术治疗,观察组在对照组基础上加用宫瘤消胶囊。比较两组临床疗效、2年复发率及并发症发生情况,同时比较2组治疗前后肌瘤体积及子宫体积、血清性激素促卵泡生成素、黄体生成素及雌二醇水平。结果观察组和对照组总有效率分别为97.12%(236/243)、86.01%(209/243),2组总有效率比较差异具有统计学意义(χ^2=19.42,P=0.00)。2组患者均获得2年随访,对照组复发率为9.47%,观察组复发率为0%,观察组2年复发率显著低于对照组,差异具有统计学意义(χ^2=24.12,P=0.00)。治疗后观察组肌瘤体积(32.18±13.24)、子宫体积(101.95±9.92)显著低于对照组(40.94±14.13)、(118.32±11.24),差异具有统计学意义(P=0.00)。治疗后观察组血清E2(3.68±0.31)水平显著高于对照组(2.14±0.22),血清LH(16.88±2.50)及FSH(12.36±1.75)水平显著低于对照组(24.76±3.05)、(18.48±2.11),差异具有统计学意义(P=0.00)。观察组并发症发生率(1.23%)低于对照组(3.70%),但2组并发症发生率比较差异无统计学意义(χ^2=3.08,P>0.05)。结论子宫肌瘤患者行射频消融术联合宫瘤消胶囊治疗,可缩小肌瘤体积、降低复发率、减少并发症,改善性激素表达,安全性高,具有进一步探讨的意义。Objective To investigate the clinical effect of radiofrequency ablation combined with Gongliuxiao capsule in the treatment of uterine myoma.Methods From 1 st June 2013 to 30 th June 2017,486 patients with uterine myoma were treated in our hospital.The patients were randomly divided into control group(n=243)and observation group(n=243).The control group was treated with radiofrequency ablation guided by abdominal ultrasound,and the observation group was treated with Gongliuxiao capsule on the basis of the control group.The clinical efficacy,2-year recurrence rate and complications were compared between the two groups.At the same time,the volume of myoma and uterine volume,and the levels of serum sex hormone(FSH,LH,E2)were compared between the two groups before and after treatment.Results The total effective rates of the observation group and the control group were 97.12%(236/243)and 86.01%(209/243),respectively.There was significant difference in the total effective rate between the two groups(χ^2=19.42,P=0.00).Both groups were followed up for 2 years.The recurrence rate was 9.47%(23/243)in the control group and 0%in the observation group.The 2-year recurrence rate in the observation group was significantly lower than that in the control group,and the difference was statistically significant(χ^2=24.12,p=0.00).The myoma volume(32.18±13.24),uterine volume(101.95±9.92)in the observation group after treatment were significantly lower than that in the control group[(40.94±14.13),(118.32±11.24)].the difference was statistically significant(t values were 7.05、17.02,P values were 0.00、0.00).After treatment,the level of serum E2 in the observation group(3.68±0.31)was significantly higher than that in the control group(2.14±0.22).The level of serum LH(16.88±2.50)and FSH(12.36±1.75)were significantly lower than those in the control group[(24.76±3.050),(18.48±2.11)](t values were 63.15、31.15、34.80,P values were 0.00、0.00、0.00).The complication rate of the observation group(1.23%)was lower than that of

关 键 词：射频消融术 宫瘤消胶囊 子宫肌瘤 临床效果 

分 类 号：R737.33[医药卫生—肿瘤]