肢体远隔缺血预适应治疗缺血性脑血管病的临床效果及对BDNF、MMP-9的影响  

Clinical Effect of Remote Limb Ischemic Precondition on Ischemic Cerebrovascular Disease and Its Effect on BDNF and MMP-9

作　　者：薛超萍 闫重辰 吕良[3] 于丽君[2] Xue Chaoping;Yan Zhongchen;Lv Liang;Yu Lijun(Department of Neurology,No.1 Affiliated Hospital of Jiamusi University,Jiamusi 154000;Qiqiha'er No.1 Hospital,Qiqiha'er 161000;Chinese People's Liberation Army Joint Service Support Unit 961 Hospital,Qiqiha'er 161000)

机构地区：[1]佳木斯大学附属第一医院神经内科,佳木斯154000 [2]齐齐哈尔市第一医院,齐齐哈尔161000 [3]中国人民解放军联勤保障部队第961医院,齐齐哈尔161000

出　　处：《数理医药学杂志》2021年第1期1-3,共3页Journal of Mathematical Medicine

摘　　要：目的:探讨肢体远隔缺血预适应治疗缺血性脑血管病的临床效果及对脑源性神经营养因子(BDNF)和基质金属蛋白酶-9(MMP-9)的影响。方法 :选择2019年2月~2020年2月某院收治的104例缺血性脑血管病患者,随机分为观察组与对照组,两组均采取积极对症治疗,观察组在此基础上实施肢体远隔缺血预适应训练,比较两组的美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数(BI)以及血清BDNF、MMP-9水平。结果:治疗前两组患者NIHSS评分的差异无统计学意义(P>0.05),治疗后两组患者的NHISS评分均降低,且观察组NIHSS评分低于对照组,差异均有统计学意义(P<0.05);治疗前两组患者BI指数的差异无统计学意义(P>0.05),治疗后两组患者的BI指数均升高,且观察组BI指数高于对照组,差异均有统计学意义(P<0.05);治疗前两组患者BDNF、MMP-9的差异无统计学意义(P>0.05),治疗后两组患者的BDNF升高、MMP-9降低,且观察组改变幅度大于对照组,差异均有统计学意义(P<0.05)。结论:肢体远隔缺血预适应能够改善缺血性脑血管病患者的神经功能、日常生活能力以及BDNF、MMP-9的表达。Objective:To explore the clinical effect of remote limb ischemic precondition on ischemic cerebrovascular disease and its effect on brain-derived neurotrophic factor(BDNF)and matrix metalloproteinase-9(MMP-9).Methods:104 patients with ischemic cerebrovascular disease admitted to a hospital from February 2019 to February 2020 were selected and randomly divided into observation group and control group.Both groups were treated with positive symptomatic treatment,and the observation group was trained with remote limb ischemic precondition on this basis.The scores of NIHSS,Barthel Index(BI),BDNF and MMP-9 in the two groups were compared.Results:Before treatment,there was no significant difference in NIHSS between the two groups(P>0.05),After treatment,the NIHSS scores of the two groups were decreased,and the NIHSS score of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in BI index between the two groups(P>0.05),After treatment,BI indexes of the two groups increased,and BI index of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in BDNF and MMP-9 between the two groups(P>0.05),After treatment,BDNF of the two groups increased and MMP-9 decreased,and the change range of the observation group was larger than that of the control group,the difference was statistically significant(P<0.05).Conclusion:Remote limb ischemic precondition can improve the neurological function,daily living ability and the expression of BDNF and MMP-9 in patients with ischemic cerebrovascular disease.

关 键 词：肢体远隔缺血预适应 缺血性脑血管病 脑源性神经营养因子 基质金属蛋白酶-9 

分 类 号：R743[医药卫生—神经病学与精神病学]