VEGF-C与Gas6在胆管癌中的表达及临床意义  

Expression and clinical significance of VEGF⁃C and Gas6 in cholangiocarcino⁃ma

作　　者：朱宇[1] 吴涯昆 龚程[1] 庞武[1] 田银生[1] ZHU Yu;WU Yakun;GONG Cheng;PANG Wu;TIAN Yinsheng(Department of Hepatobiliary Surgery,Suining Central Hospital,Suining,Sichuan,China,629000)

机构地区：[1]四川省遂宁市中心医院肝胆外科,四川遂宁629000

出　　处：《分子诊断与治疗杂志》2020年第12期1674-1677,1681,共5页Journal of Molecular Diagnostics and Therapy

基　　金：四川省卫生和计划生育委员会课题(17ZD020)。

摘　　要：目的探究血管内皮生长因子C(VEGF-C)与生长停滞特异性基因6(Gas6)在胆管癌中的表达及临床意义。方法选取本院2016年5月至2019年8月122例胆管癌患者作为研究对象,检测对比癌组织、癌旁正常组织中VEGF-C、Gas6阳性表达率,分析VEGF-C、Gas6与临床特征相关性。统计胆管癌患者1年生存率,采用Kaplan-Meier曲线进行生存分析。结果癌组织中VEGF-C、Gas6阳性表达率高于癌旁正常组织,差异有统计学意义(P<0.05)。VEGF-C与动静脉受侵、淋巴结转移、临床分期、Gas6呈正相关,差异有统计学意义(P<0.05)。Gas6与动静脉受侵、淋巴结转移、临床分期、VEGF-C呈正相关,差异有统计学意义(P<0.05)。将年龄、性别、肿瘤部位、肿瘤直径、组织学分级、病理类型等因素控制后,VEGF-C、Gas6仍与动静脉受侵、淋巴结转移、临床分期显著相关(P<0.05);随访1年,失访8例。114例胆管癌患者1年生存率为65.79%(75/114)。Kaplan-Meier曲线分析,VEGF-C、Gas6阳性表达患者1年生存率低于阴性表达患者,差异有统计学意义(P<0.05)。结论 VEGF-C、Gas6联合检测有助于为临床评估病情、预测生存状况提供参考依据。Objective To explore the expression and clinical significance of vascular endothelial growth factor C(VEGF⁃C)and growth arrest specific gene 6(Gas6)in cholangiocarcinoma.Methods 122 patients with cholangiocarcinoma from May 2016 to August 2019 in our hospital were selected as the research objects.The positive expression rates of VEGF⁃C and Gas6 in cancer tissues and normal tissues adjacent to cancer were detected,and the correlation between VEGF⁃C and Gas6 and clinical features was analyzed.The 1⁃year survival rate of patients with cholangiocarcinoma was counted,and Kaplan⁃Meier curve was used for survival analysis.Results The positive expression rate of VEGF⁃C and Gas6 in cancer tissues was higher than that in normal tissues adjacent to cancer,the difference was statistically significant(P<0.05);VEGF⁃C was positively correlated with arteriovenous invasion,lymph node metastasis,clinical stage,and Gas6,the difference was statistically significant(P<0.05);Gas6 was positively correlated with arteriovenous invasion,lymph node metastasis,clinical stage,and VEGF⁃C,the difference was statistically significant(P<0.05).After controlling for factors such as age,gender,tumor site,tumor diameter,histological grade,and pathological type,VEGF⁃C and Gas6 were still significantly associated with arteriovenous invasion,lymph node metastasis,and clinical stage,and the difference was statistically significant(P<0.05).Followed up for 1 year,8 cases were lost to follow⁃up.The 1⁃year survival rate of 114 patients with cholangiocarcinoma was 65.79%(75/114);Kaplan⁃Meier curve analysis showed that the 1⁃year survival rate of patients with positive expression of VEGF⁃C and Gas6 was lower than that of patients with negative expression,the difference was statistically significant(P<0.05).Conclusion The positive expression rate of VEGF⁃C and Gas6 Combined detection is helpful for clinical evaluation of the disease and prediction of survival and provide a reference basis.

关 键 词：胆管癌 血管内皮生长因子C 生长停滞特异性基因6 临床特征 生存分析 

分 类 号：R735.8[医药卫生—肿瘤]