乳腺癌最大弹性模量值、病灶大小及分子分型间的相关性研究  

Study on the Correlation between the Maximum Elastic Modulus Value,Lesion Size and Molecular Classification of Breast Cancer

作　　者：邓敏君[1] 钟娜[1] 吴佳偿 DENG Minjun;ZHONG Na;WU Jiachang(Guangdong Second Traditional Chinese Medicine Hospital,Guangzhou 510095,China;不详)

机构地区：[1]广东省第二中医院,广东广州510095

出　　处：《中外医学研究》2020年第35期57-59,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：广东省医学科学技术研究基金项目(B201867)。

摘　　要：目的:探讨乳腺癌最大弹性模量值、病灶大小及分子分型间的相关性。方法:回顾性分析经手术病理证实的65个病灶,上述病灶在术前均进行了肿块大小的测量及超声剪切波弹性成像并测量最大弹性模量值;术后进行免疫组化检查,记录雌激素受体(ER)、孕激素受体(PR)、人类表皮生长因子受体-2(HER-2)及增殖细胞核抗原-67(Ki67)情况。分析浸润性导管癌最大弹性模量值与其分子分型的相关性。结果:非基底样型(Luminal A型、Luminal B型、HER-2过表达型)最大弹性模量值>100 kPa的病灶占较大病灶(>20 mm)75.8%,最大弹性模量值>100 kPa的病灶占较小病灶(≤20 mm)30.8%;基底样型(三阴型)最大弹性模量值>100 kPa的病灶占较大病灶(>20 mm)100%,最大弹性模量值>100 kPa的病灶占较小病灶(≤20 mm)83.3%。Luminal A型、Luminal B型、HER-2过表达型、基底样型最大弹性模量值>100 kPa的病灶占总病例数的60%;各自病例数的40%、55%、60%、90%。非基底样型的病灶最大弹性模量值与病灶的大小的差异有统计学意义(P<0.05);基底样型的病灶最大弹性模量值与病灶的大小差异无统计学意义(P>0.05);病灶最大弹性模量值与病灶的分子分型差异无统计学意义(P>0.05)。结论:在乳腺浸润性导管癌的分子分型中,非基底样型的病灶最大弹性模量值与病灶的大小呈正相关;基底样型的病灶最大弹性模量值与病灶的大小没有相关性。术前通过测量病灶最大弹性模量值无法预测病灶的分子分型。Objective:To explore the correlation between the maximum elastic modulus,lesion size and molecular classification of breast cancer.Method:A total of 65 confirmed lesions by surgical pathology were retrospective analyzes.The above lesions were measured for tumor size and ultrasound shear wave elastography before surgery and the maximum elastic modulus value was measured;immunohistochemical examination was performed after operation and records estrogen receptor (ER),progesterone receptor (PR),human epidermal growth factor receptor-2 (HER-2) and proliferating cell nuclear antigen-67 (Ki67).The correlation between the maximum elastic modulus of invasive ductal carcinoma and its molecular typing was analyzed.Result:The non-basal-like type (Luminal A type,Luminal B type,HER-2 overexpression type) lesions with the maximum elastic modulus value>100 kPa accounted for 75.8% of the larger lesions (>20 mm),and the maximum elastic modulus value>100 kPa lesions accounted for 30.8% of smaller lesions (≤20 mm);lesions with basal-like (three-negative type) maximum elastic modulus value>100 kPa accounted for 100% of larger lesions (>20 mm),and lesions with maximum elastic modulus value>100 kPa accounted for 83.3% of small lesions (≤20 mm).Luminal A type,Luminal B type,HER-2 overexpression type,basal-like type maximum elastic modulus value>100 kPa lesions accounted for 60% of the total number of cases;40%,55%,60%,90% of the respective cases.The difference between the maximum elastic modulus of non-basal-like lesions and the size of the lesions was statistically significant (P<0.05);the difference between the maximum elastic modulus of non-basal-like lesions and the size of the lesions was not statistically significant (P>0.05).The maximum elastic modulus value of the lesion had no statistical significance with the molecular typing of the lesion (P>0.05).Conclusion:In the molecular classification of invasive ductal carcinoma of the breast,the maximum elastic modulus value of non-basal-like lesions is positively correlated with t

关 键 词：剪切波弹性成像 乳腺癌 分子分型 

分 类 号：R737.9[医药卫生—肿瘤]