疾病相关性小胶质细胞在创伤性颅脑损伤后神经变性中的作用机制及展望  

Mechanism and prospect of disease-associated microglia in neurodegeneration after traumatic brain injury

作　　者：巫扬标 周贤喆 李仕鹏 吕雯奇 姚杰然 陈祥荣[1] Wu Yangbiao;Zhou Xianzhe;Li Shipeng;Lyu Wenqi;Yao Jieran;Chen Xiangrong(Second Clinical Medical College,Fujian Medical University,Quanzhou 362000,China)

机构地区：[1]福建医科大学第二临床医学院,泉州362000

出　　处：《中华神经医学杂志》2020年第12期1283-1287,共5页Chinese Journal of Neuromedicine

基　　金：福建省自然科学基金(2019J01168);福建省科技创新联合基金(2017Y9084)。

摘　　要：创伤性颅脑损伤(TBI)诱导神经变性和神经退行性改变,这一病理过程与小胶质细胞密切相关。小胶质细胞的病理生理功能与其不同细胞亚型密切相关,其中疾病相关性小胶质细胞(DAM)是在最近中枢神经系统变性疾病病变部位发现的一种特殊类型小胶质细胞亚型,被认为是导致神经变性的重要因素。深入探讨DAM在TBI后神经变性病理机制中的作用,可为理解和治疗TBI后神经变性提供新的线索。故本文围绕DAM与TBI后神经变性的研究进展综述如下。The pathological processes of neurodegeneration and neurodegenerative changes after traumatic brain injury(TBI)are closely related to microglia.The pathophysiological functions of microglia are closely correlated to their different cell subtypes.Disease-related microglia(DAM)are a special subtype of microglia,which recently discover on the lesions of degenerative diseases of the central nervous system.DAM are identified as important cells that induce neurodegeneration.The in-depth discussion of DAM role in pathological mechanism of neurodegeneration after TBI provides new clues for understanding and treating neurodegeneration after TBI;therefore,this article focuses on the above content and summarizes the research progress of DAM and neurodegeneration after TBI.

关 键 词：小胶质细胞 创伤性颅脑损伤 神经变性 神经变性相关分子模式 

分 类 号：R651.15[医药卫生—外科学]