缺血再灌注损伤与细胞焦亡的相关性研究进展  

Review of Correlation between Ischemia-reperfusion Injury and Pyroptosis

作　　者：王小莹 刘作金[2] 申丽娟 WANG Xiao-ying;LIU Zuo-jin;SHEN Li-juan(Dept.of Anesthesiology,3rd Affiliated Hospital of Chongqing Medical University,Chongqing 401120;Dept.of Hepatobiliary Surgery,2nd Affiliated Hospital of Chongqing Medical University,Chongqing 400010;Dept.of Pathology,School of Basic Medical Science,Kunming Medical University,Kunming Yunnan 650500,China)

机构地区：[1]重庆医科大学附属第三医院麻醉科,重庆401120 [2]重庆医科大学附属第二医院肝胆外科,重庆400010 [3]昆明医科大学基础医学院病理学教研室,云南昆明650500

出　　处：《昆明医科大学学报》2020年第12期142-147,共6页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(81170442)。

摘　　要：缺血再灌注损伤是由病理因素或治疗方式所致的组织暂时缺血,恢复血流后引起组织损伤,能导致相关器官功能障碍。这种损伤与各器官中相关细胞中发生的炎性损伤密切相关。细胞焦亡是研究发现的形态学上与凋亡相似,伴随炎症反应发生的细胞程序性死亡。近年来多项研究证明缺血再灌注损伤的发病机制可能与细胞焦亡相关。细胞焦亡过程中各种炎症因子活化在此环节中起关键作用。结合文献就细胞焦亡与心、脑、肝脏、肾脏这几个重要脏器的缺血再灌注损伤间的关系作一综述。Ischemia-reperfusion injury is temporary tissue ischemia caused by pathological factors or treatments.After restoring blood flow,it causes tissue damage,which can lead to related organ dysfunction.This injury is closely related to the inflammatory injury occurring in the cells in each organ.Pyroptosis is a type of programmed cell death associated with inflammation that is morphologically similar to apoptosis.In recent years,a number of studies demonstrated that the pathogenesis of ischemia-reperfusion injury may be related to pyroptosis.The activation of various inflammatory factors during pyroptosis plays a key role in this process.This paper provides a review on the association between pyroptosis and ischemia-reperfusion injury of heart,brain,liver and kidney.

关 键 词：细胞焦亡 缺血再灌注损伤 半胱天冬酶-1 半胱天冬酶-11 GSDMD蛋白 白介素-1Β 白介素-18 

分 类 号：R365[医药卫生—病理学]