组蛋白去甲基化酶KDM2B在疾病发生过程中的功能研究  

Function of histone demethylase KDM2B in the process of disease

作　　者：杜鸿斌 刘琳琳[1,2] 孙梦莹 王丹宇 赵春玲 田春艳[2] DU Hongbin;LIU Linlin;SUN Mengying;WANG Danyu;ZHAO Chunling;TIAN Chunyan(Key Laboratory of Immunology in Universities of Shandong Province,Weifang Medical College,Weifang 261053,China;Beijing Institute of Lifeomics,Academy of Military Medical Sciences,Beijing 102206,China;Key Laboratory of Biopharmaceutics in Universities of Shandong Province,Weifang Medical College,Weifang 261053,China)

机构地区：[1]潍坊医学院山东省高校免疫学重点实验室,潍坊261053 [2]军事医学研究院生命组学研究所,北京102206 [3]潍坊医学院山东省高校生物药物重点实验室,潍坊261053

出　　处：《生命的化学》2020年第10期1800-1807,共8页Chemistry of Life

基　　金：国家自然科学基金项目(31771563,81572578);蛋白质组学国家重点实验室开放基金项目(SKLP-O201802);国家级大学生创新创业训练项目(201810438010);潍坊医学院大学生科技创新基金项目(KX2018019)。

摘　　要：KDM2B(Lysine-specific demethylase 2B)是组蛋白去甲基化酶家族的一员,能够特异性地使组蛋白H3K36me2、H3K4me3和H3K79me位点去甲基化。KDM2B能够参与多种细胞活动,如细胞衰老、细胞分化、细胞增殖、细胞凋亡和干细胞的自我更新等,进而在多种疾病包括肿瘤、炎症和神经性疾病中发挥重要作用。本文对KDM2B在多种疾病发生发展过程中的功能和机制进行了综述。Lysine-specific demethylase 2B(KDM2B),a member of the histone demethylase family,specifically demethylates the histones H3K36me2,H3K4me3 and H3K79me.KDM2B can participate in a variety of cellular activities,such as cell senescence,differentiation,proliferation,apoptosis and self-renewal of stem cells,and then play an important role in a variety of diseases,including tumors,inflammatory and neurological diseases.This review summarized the functions and mechanisms of KDM2B in the occurrence and development of various diseases.

关 键 词：组蛋白去甲基化酶 甲基化修饰 肿瘤 炎症 神经性疾病 

分 类 号：R363[医药卫生—病理学]