他莫昔芬致急性胰腺炎一例并文献回顾  

Acute pancreatitis caused by tamoxifen:case report and literature review

作　　者：林婷[1] 赵硕[1] 高洁[1] 刘司南 王铮[1] 刘昌[1] LIN Ting;ZHAO Shuo;GAO Jie;LIU Si-nan;WANG Zheng;LIU Chang(Department of Surgical Intensive Care Unit,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]西安交通大学第一附属医院外科ICU,陕西西安710061

出　　处：《实用药物与临床》2020年第12期1129-1130,共2页Practical Pharmacy and Clinical Remedies

摘　　要：一例43岁女性患者既往患有乳腺癌,2年前行乳腺癌改良根治术后长期口服他莫昔芬,现以急性胰腺炎收治入院,既往无胆结石、高脂血症病史,结合患者用药史,考虑与他莫昔芬相关,入院后给予禁饮食、抑酸、抑酶、补液、抗感染、CRRT、降脂、腹腔穿刺置管引流等对症支持治疗,后因腹腔感染控制欠佳行腹腔坏死组织清除引流术,术后因感染性休克自动出院。A 43-year-old female patient had breast cancer and had been taking oral tamoxifen after modified radical mastectomy for breast cancer 2 years ago.The patient was admitted to hospital for acute pancreatitis with no previous history of gallstones or hyperlipidemia.Based on her medication history,it was considered that the pancreatitis was related to tamoxifen.After admission,symptomatic supportive treatment,such as fasting,acid suppression,enzyme suppression,rehydration therapy,anti-infection,CRRT,lipid reduction,and abdominal puncture and drainage,was given.Abdominal necrosis tissue was removed and drained due to poor control of abdominal infection.The patient was finally discharged from hospital automatically due to septic shock.

关 键 词：他莫昔芬 急性胰腺炎 乳腺癌 

分 类 号：R576[医药卫生—消化系统]