风寒感冒颗粒挥发油的提取及包合工艺研究  

Study on Inclusion Technology of Volatile Oil in Fenghan Ganmao Keli

作　　者：吴萍 郑广晶 赵源慧 李亚东 高嵩 崔宪利 徐建 WU Ping;ZHENG Guangjing;ZHAO Yuanhui;LI Yadong;GAO Song;CUI Xianli;XU Jian(Key Laboratory of Key Engineering Technology for Standardization of Traditional Chinese Medicine in Jilin Province,Jilin Xiuzheng Pharmaceutical New Drug Development Co.,Ltd.,Changchun 130103,China;Jilin Changbaishan Pharmaceutical Group Co.,Ltd.,Baishan 134300,Jilin Province,China)

机构地区：[1]吉林修正药业新药开发有限公司,吉林省中药标准化关键工程技术重点实验室,长春130103 [2]吉林长白山药业集团股份有限公司,吉林白山134300

出　　处：《吉林中医药》2020年第12期1647-1650,共4页Jilin Journal of Chinese Medicine

基　　金：吉林省科技发展计划项目(20170311036YY)。

摘　　要：目的优选风寒感冒颗粒中紫苏叶、防风、白芷挥发油的提取和β-环糊精包合最佳工艺。方法以挥发油提取量为指标,单因素试验考察挥发油的提取工艺;以挥发油包合率为指标,比较研磨法与饱和水溶液法的包合效果;采用正交试验法,以β-环糊精用量、包合温度及包合时间为影响因素,以挥发油包合率及包得率为考察指标,优选挥发油最佳包合工艺条件。结果挥发油最佳提取条件为加5倍量水,浸泡1 h,水蒸气蒸馏5 h,收集挥发油;饱和水溶液法挥发油包合率高于研磨法;挥发油包合最佳工艺条件为挥发油与β-环糊精的投料比l:10,包合转数为50 r/min,包合时间为4 h;验证试验结果表明包合率均在92%以上。结论优选的挥发油β-环糊精包合工艺稳定、可行,为风寒感冒颗粒的产业化生产提供科学依据。Objective To optimize the optimal process of extraction andβ-cyclodextrin inclusion in the volatile oil of perilla leaves,wind-proof and white peony in Fenghan Ganmao Keli.Methods The extraction of volatile oil was used as the index,and the extraction process of volatile oil was investigated by single factor experiment.The inclusion rate of volatile oil was used as the index and comparison of the inclusion effect of grinding method and saturated aqueous solution method.The orthogonal test method was used to optimize the optimal process conditions of the volatile oil and the amount ofβ-cyclodextrin,the inclusion temperature and the inclusion time were taken as the influencing factors,and the inclusion rate and yield of volatile oil was taken as the index.Results The optimal extraction conditions of volatile oil were as follows:adding 5 times of water,soaking for 1 hour,steam distillation for 5 hours,collecting volatile oil;the saturated oil solution was higher than the grinding method;the optimum process conditions for volatile oil inclusion were:the ratio of volatile oil toβ-cyclodextrin is 1:10,the inclusion convolution is 50r/min,and the inclusion time is 4 hour;the verification test results show that the inclusion ratio is above 92%.Conclusion The optimal volatile oilβ-cyclodextrin,inclusion process is stable and feasible,providing a scientific basis for the industrial production of Fenghan Ganmao Keli.

关 键 词：风寒感冒颗粒 挥发油 Β-环糊精 

分 类 号：R285[医药卫生—中药学]