银杏叶片联合胞磷胆碱钠片治疗血管性痴呆临床研究  

Clinical Study on Ginkgo Leaf Tablets Combined with Citicoline Sodium Tablets for Vascular Dementia

作　　者：方锦才[1] 张佳克[1] 安海龙[1] FANG Jincai;ZHANG Jiake;AN Hailong

机构地区：[1]武警浙江省总队医院脑外科,浙江嘉兴314000

出　　处：《新中医》2020年第23期57-60,共4页New Chinese Medicine

摘　　要：目的:观察银杏叶片联合胞磷胆碱钠片治疗血管性痴呆的临床疗效。方法:将60例波动期血管性痴呆患者随机分为对照组和观察组,各30例。对照组在常规治疗的基础上给予胞磷胆碱钠片治疗,观察组在对照组的基础上加用银杏叶片治疗。2组疗程均为3个月,评估患者临床疗效及不良反应发生情况,检测2组治疗前后两侧大脑中动脉血流速度及外周血同型半胱氨酸(Hcy)水平,并应用Barthel指数(BI)表评估患者日常生活能力、简明精神状态检查量表(MMSE)评估患者精神状态。结果:总有效率观察组为83.33%,对照组为53.33%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组患者大脑中动脉血流速度较治疗前升高(P<0.05),外周血Hcy水平较治疗前降低(P<0.05);且观察组2项指标改善较对照组更显著(P<0.05)。治疗后,2组患者MMSE评分、BI指数均较治疗前明显升高(P<0.05),且观察组2项指标均高于对照组(P<0.05)。不良反应发生率观察组为20.00%,对照组为26.67%,2组比较,差异无统计学意义(P>0.05)。结论:银杏叶片联合胞磷胆碱钠片治疗波动期血管性痴呆患者疗效肯定,效果优于单纯西药治疗。Objective:To observe the clinical effect of Ginkgo leaf tablets combined with citicoline sodium tablets for vascular dementia.Methods:A total of 60 cases of patients with vascular dementia during the fluctuation period were randomly divided into the control group and the observation group,30 cases in each group.The control group was given citicoline sodium tablets based on general treatment,and the observation group was additionally given Ginkgo leaf tablets based on the treatment of the control group.Both groups were treated for three months.The clinical effect and incidence of adverse reactions of patients were evaluated.Artery blood flow velocities in both sides of the brain and levels of homocysteine(Hcy)in peripheral blood before and after treatment were detected in the two groups.Activities of daily living of patients were evaluated via Barthel Index(BI)form,and their mental state was evaluated via the Mini-Mental State Examination(MMSE).Results:The total effective rate was 83.33%in the observation group and 53.33%in the control group,the difference being significant(P<0.05).After treatment,when compared with those before treatment,artery blood flow velocities in the brain in the two groups were increased(P<0.05),and the levels of Hcy in peripheral blood were decreased(P<0.05);the improvement of above two indexes in the observation group was more significant than that in the control group(P<0.05).After treatment,the scores of MMSE and BI in the two groups were significantly increased when compared with those before treatment(P<0.05),and the above two scores in the observation group were higher than those in the control group(P<0.05).The incidence of adverse reactions was 20.00%in the observation group and 26.67%in the control group,differences being not significant(P>0.05).Conclusion:The therapy of Ginkgo leaf tablets combined with citicoline sodium tablets has significant curative effect in treating patients with vascular dementia during the fluctuation period,which is better than that of simple western me

关 键 词：血管性痴呆 银杏叶片 胞磷胆碱钠片 简明精神状态检查量表 

分 类 号：R749.16[医药卫生—神经病学与精神病学]