Heightened protein-translation activities in mammalian cells and the disease/treatment implications  

作　　者：Chung-I Wu Haijun Wen 

机构地区：[1]State Key Laboratory of Biocontrol,School of Life Sciences,Sun Yat-sen University,China

出　　处：《National Science Review》2020年第12期1851-1855,共5页国家科学评论（英文版）

基　　金：supported by the National Natural Science Foundation of China(31730046,91731000 and 81972691);the Guangdong Basic and Applied Basic Research Foundation(2020B1515020030);the National Key Research and Development Project(2020YFC0847000);the 985 Project(33000-18841204).

摘　　要：After cells divide,the new cells have to synthesize all the necessary cellular components in time for the next division.There is a lower bound of time required for cells to double their contents.For mammalian cells,this lower bound may be around 20 hours,as artificial selection for faster-dividing cells has not pushed cell lines to go below this'barrier*in doubling time.The occasional exceptions are those that appear to‘prove the rule’.For example,yeast cells can divide once every 1.5 hours[1,2];and the fastest rate of cell divisions in metazoans may be that of the embryonic cells of Drosophila,at 5 minutes per cycle[3].Thus,at least for eukaryotic cells,the rate-limiting step is not the replication of DNA.

关 键 词：dividing TREATMENT doubling 

分 类 号：Q952[生物学—动物学]