炎性指标对高龄脑卒中患者肺部感染的早期预测价值  

The early prediction effect of inflammatory indicators on pulmonary infection in elderly stroke patients

作　　者：顾辨辨 何媛媛 李静[1] 王璇 张薇薇 孙梦雯 严光 Gu Bianbian;He Yuanyuan;Li Jing;Wang Xuan;Zhang Weiwei;Sun Mengwen;Yan Guang(Department of Geriatrics,the First Affiliated Hospital of University of Science and Technology of China,Hefei 230001,China)

机构地区：[1]中国科学技术大学附属第一医院(安徽省立医院)老年医学科,合肥230001

出　　处：《中国临床保健杂志》2020年第6期766-769,共4页Chinese Journal of Clinical Healthcare

基　　金：安徽省心血管病研究所科研项目(KF201801)。

摘　　要：目的探讨炎性指标对高龄脑卒中患者发生肺部感染的早期预测价值。方法分析2019年1月1日至2019年12月31日符合纳入标准的中国科学技术大学附属第一医院老年医学科的89例高龄脑卒中患者。将研究对象分为高龄脑卒中合并肺部感染组及非感染对照组。记录患者入院时的白细胞(WBC),中性粒细胞(NEUT),中性粒细胞百分比(NEU%),血小板(PLT),淋巴细胞(LYM),依据上述指标计算中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)及全身免疫炎症指数(SII)的数值,探讨两组间上述指标的差异,绘制受试者工作曲线评价NLR、PLR及SII等炎性指标对高龄脑卒中患者发生肺部感染的早期预测作用。结果肺部感染组的WBC、NEUT、NEU%、PLT、NLR、PLR、SII水平均显著高于非感染组,差异有统计学意义(P<0.05)。NLR、PLR、SII预测高龄脑卒中患者合并肺部感染的ROC曲线下面积(AUC)分别为0.876(0.805~0.948),0.724(0.612~0.836),0.859(0.779~0.938),敏感度分别为73.2%、56.1%、65.9%,特异度分别为89.6%、85.4%、91.7%。结论NLR、PLR及SII对高龄脑卒中患者肺部感染的发生均具有一定的早期预测价值。Objective To determine the diagnostic value of eutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),systemic immune-inflammation index(SII)for the occurrence of pulmonary infection in elderly stroke patients.Methods A total of 89 elderly stroke patients in The First Affiliated Hospital of University of Science and Technology of China who met the inclusion criteria from January 1,2019 to December 31,2019 was retrospectively analyzed.The patients were divided into the elderly stroke combined with pulmonary infection group and the non-infection group.We recorded the white blood cells,neutrophils,NEU%,platelets,lymphocytes and calculate the values of NLR,PLR and SII based on the above indicators.To explore the differences of the above indicators between the two groups and ROC was used to evaluate the early predictive effects of inflammatory indicators such as NLR,PLR and SII on the occurrence of pulmonary infection in elderly stroke patients.Results The levels of WBC,NEUT,NEU%,PLT,NLR,PLR,and SII in the pulmonary infection group were higher than those in the no infection group,and the difference was statistically significant(P<0.05).The AUC of NLR,PLR,SII to predict the pulmonary infection are 0.876(0.805-0.948),0.724(0.612-0.836),0.859(0.779-0.938)respectively.The sensitivity was 73.2%,56.1%,65.9%,and the specificity was 89.6%,85.4%,91.7%respectively.Conclusion NLR,PLR and SII have effective predictive value on the occurrence of pulmonary infection in elderly stroke patients.

关 键 词：卒中 肺疾病 早期诊断 老年人 80以上 

分 类 号：R73[医药卫生—肿瘤]