青年结直肠癌的临床病理特征分析  

Clinicopathological characteristics of colorectal cancer in young patients

作　　者：彭翰斐 张锦标 邓欣 罗迦耀 龚瑾[2] Peng Hanfei;Zhang Jinbiao;Deng Xin;Luo Jiayao;Gong Jin(DivisionⅡof General Surgery,Yuedong Hospital,The Third Affiliated Hospital of Sun Yat-sen University,Meizhou 514000,Guangdong,China;Department of Gastrointestinal Surgery,The First Affiliated Hospital of Jinan University,Guangzhou 510630,Guangdong,China)

机构地区：[1]中山大学附属第三医院粤东医院普通外科二区,广东梅州514000 [2]暨南大学附属第一医院胃肠外科,广东广州510630

出　　处：《结直肠肛门外科》2020年第6期706-709,717,共5页Journal of Colorectal & Anal Surgery

摘　　要：目的比较青年结直肠癌与非青年结直肠癌患者临床病理特征,了解青年结直肠癌的发病特点。方法回顾性分析2012年1月至2019年1月于暨南大学附属第一医院住院治疗的结直肠癌患者临床资料,以40岁为界值分为两组,共纳入50例患者进入青年结直肠癌组及80例患者进入非青年结直肠癌组,记录并比较两组的临床病理特征。结果两组获得最终病理方式、组织病理学类型比较,差异均有统计学意义(均P<0.05)。青年结直肠癌组有6例患者通过肠镜检查获得最终病理标本(2例接受根治性手术,4例接受姑息性手术),非青年结直肠癌组均接受根治性手术。两组性别、家族史、首诊症状、AFP、CEA、CA19-9、手术性质、肿瘤部位及Dukes分期比较,差异均无统计学意义(均P>0.05)。两组肿瘤分化程度比例分布呈现一致趋势,组间比较差异无统计学意义(P>0.05)。结论青年结直肠癌肿瘤恶性程度相对更高,确诊时肿瘤分期有较晚的趋势,早期的肠镜检查将有助于实现疾病早诊断,临床工作中应予以重视。Objectives To compare clinicopathological characteristics between young and older patients with colorectal cancer and analyze young patients’characteristics.Methods This was a retrospective analysis of patients with colorectal cancer treated at the First Affiliated Hospital of Jinan University between January 2012 and January 2019.Patients were divided into young(n=50)and older patients(n=80)with the age cutoff of 40.Clinicopathological characteristics were compared between the two groups.Results The two groups differed significantly in obtaining specimen and histology types(P<0.05).Six specimens were ob⁃tained in young patients through colonoscopy,including two radical surgery and four palliative surgery.All older patients re⁃ceived radical surgery.The two groups were similar in sex,family history,presenting symptoms,Alpha-fetoprotein,carcinoembry⁃onic antigen,and cancer antigen 19-9,purpose of surgery,tumor location,and Dukes stage(P>0.05).Young and older patients shared a similar trend of distribution of tumor differentiation(P>0.05).Conclusion In young patients with colorectal cancer,the degree of malignancy was relatively higher.At the time of diagnosis,there was a trend that young patients had more advanced tumor stages.Colonoscopy is beneficial for early diagnosis and should play a crucial role in clinical management.

关 键 词：结直肠癌 青年患者 临床病理特征 

分 类 号：R735.34[医药卫生—肿瘤]