2-氨基-5-巯基-1,3,4-噻二唑席夫碱类衍生物的合成及抑菌活性  

Synthesis and Antibacterial Activity of 2-Amino-5-Mercapto-1,3,4-Thiiodiazole Schiff Base Derivatives

作　　者：薛蒙伟 朱晔辰 戚诗媛 张敦林 XUE Meng-wei;ZHU Ye-chen;QI Shi-yuan;ZHANG Dun-lin(School of Environmental Science,Nanjing Xiaozhuang University,Nanjing 211171,China)

机构地区：[1]南京晓庄学院环境科学学院,江苏南京211171

出　　处：《南京晓庄学院学报》2020年第6期23-26,共4页Journal of Nanjing Xiaozhuang University

基　　金：2020年江苏省大学生创新训练计划(202011460041Y).

摘　　要：以三乙胺为溶剂,二硫化碳和氨基硫脲在78~80℃反应1.5 h,得到2-氨基-5-巯基-1,3,4-噻二唑,产率69%,再将其与取代苯甲醛反应,得到一系列的2-氨基-5-巯基-1,3,4-噻二唑席夫碱5a^5f,产率66%~83%,所得化合物结构经1HNMR、13CNMR、FT-IR和HRMS验证.生物活性测试表明,化合物5f对番茄灰霉病菌、油菜菌核病菌和大豆灰斑病菌的有较高的抑制作用.With triethylamine as solvent,carbon disulfide and thiourea were reacted at 78~80℃for 1.5 h to give 2-amino-5-thiol-1,3,4-thiazolyldiazole,yield 69%.Then a series of 2-amino-5-mercapto-1,3,4-thiiodiazole schiff base derivatives 5a^5f were synthesized via the condensation reaction of 2-amino-5-thiol-1,3,4-thiazolyldiazole and substituted benzaldehyde with the yield 66%~83%.The structures of the synthesized compounds were identified by means of 1H NMR,13 C NMR,FT-IR and HRMS techniques.Preliminary bioactivity tests showed that compound 5f had a high inhibitory effect on Tomato Botrytis Cinerea,Rape Sclerotinia Sclerotiorum and Cercospora Sojina Hara.

关 键 词：2-氨基-5-巯基-1 3 4-噻二唑 苯甲醛 席夫碱 抑菌活性 

分 类 号：O626[理学—有机化学]