固有免疫与非酒精性脂肪肝的研究进展  

Progress in the study on innate immunity and non-alcohol fatty liver disease

作　　者：娄经风 鄢光宇 黄志军[1] 袁洪[1] 陆瑶[1] LOU Jingfeng;YAN Guangyu;HUANG Zhijun;YUAN Hong;LU Yao(Center of Clinical Pharmacology,Third Xiangya Hospital,Central South University,Changsha 410013,China)

机构地区：[1]中南大学湘雅三医院临床药理中心,长沙410013

出　　处：《中南大学学报（医学版）》2020年第12期1464-1468,共5页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金(81800393);湖南省自然科学基金(2018JJ3783)。

摘　　要：非酒精性脂肪性肝病(non-alcohol fatty liver disease,NAFLD)的发病率逐年升高,其所诱导的相关心血管事件等也成为目前慢性病管理的重大问题。固有免疫的激活与NAFLD的发生、发展密切相关,参与的免疫细胞为Kupffer细胞、中性粒细胞、树突状细胞及自然杀伤T淋巴细胞,并通过模式识别受体介导的固有免疫相关信号的激活而发挥作用。The incidence of non-alcohol fatty liver disease(NAFLD)is increasing year by year,and the relevant cardiovascular events have become a major problem in chronic diseases management.The activation of innate immunity is closely related to the development of NAFLD.The immune cells include Kupffer cells,neutrophils,dendritic cells,and natural killer T cells,which acts through the activation of innate immunity-related signals mediated by pattern recognition receptors.

关 键 词：非酒精性脂肪肝 固有免疫 新靶点 治疗方法 

分 类 号：R575.5[医药卫生—消化系统]