P16、Ki-67免疫组化染色在宫颈上皮内瘤变分级中的诊断价值  

Diagnostic value of P16,Ki-67 immunohistochemical staining in cervical intraepithelial neoplasia classification

作　　者：史勉 SHI Mian(Department of Pathology,General Hospital of Angang Group,Anshan,Liaoning,114000,China)

机构地区：[1]鞍钢集团公司总医院病理科,辽宁鞍山114000

出　　处：《当代医学》2021年第2期63-65,共3页Contemporary Medicine

摘　　要：目的探讨应用P16、Ki-67免疫组化染色在宫颈上皮内瘤变(CIN)分级中的诊断价值。方法选取2017年1月至2019年6月本院接诊的高度疑似为CIN患者200例。所有患者均接受P16、Ki-67免疫组化染色体诊断,将手术组织病理结果作为金标准,分析P16、Ki-67免疫组化染色体诊断效能。结果 200例高度疑似CIN的患者经手术组织病理活检结果显示,16例炎症反应患者,占比8%;CINⅠ级76例,占比38.00%;CINⅡ级60例,占比30.00%;CINⅢ级30例,占比15.00%;宫颈癌18例,占比9.00%。P16、Ki-67用于CIN分级鉴别诊断与病理结果Kappa值分别为0.883、0.891,一致性好。结论 P16、Ki-67在CIN的发生、发展中具有密切相关的联系,两者的预测价值均较高,对CIN早发现、早诊断、早治疗具有重要意义。Objective To investigate the diagnostic value of P16、Ki-67 immunohistochemical staining in cervical intraepithelial neoplasia(CIN)grade.Methods From January 2017 to June 2019,200 CIN patients admitted to our hospital were selected.All patients received P16,Ki-67 immunohistochemical chromosome diagnosis,the results of histopathology as the gold standard,analysis of P16,Ki-67 immunohistochemical chromosome diagnostic efficacy.Results The results of surgical histopathological biopsy of 200 patients with highly suspected CIN showed that 16 patients had inflammatory reaction,accounting for 8%;76 cases of CINⅠ,accounting for 38.00%;60 cases of CINⅡ,accounting for 30.00%;30 cases of CINⅢ,accounting for 15.00%;18 cases of cervical cancer,accounting for 9.00%.The Kappa values of P16 and Ki-67 used in the differential diagnosis of CIN classification and pathological results were 0.883 and 0.891 respectively,with good consistency.Conclusion P16 and Ki-67 are closely related to the occurrence and development of CIN,and both have high predictive value,which are of great significance for early detection,early diagnosis and early treatment of CIN.

关 键 词：宫颈上皮内瘤变 P16 KI-67 免疫组化染色体 

分 类 号：R737.33[医药卫生—肿瘤]