内质网应激在牙周炎影响全身疾病过程中的作用  

Role of endoplasmic reticulum stress in periodontitis affecting systemic diseases

作　　者：李鑫 李艳 丁旭[1] 夏博园 于维先[1] Li Xin;Li Yan;Ding Xu;Xia Boyuan;Yu Weixian(Dept.of Periodontics,Hospital of Stomatology,Jilin University&Jilin Provincial Key Labo-ratory of Tooth Development and Bone Remodeling,Changchun 130021,China)

机构地区：[1]吉林大学口腔医院牙周病科,吉林省牙发育及颌骨重塑与再生重点实验室,长春130021

出　　处：《国际口腔医学杂志》2021年第1期12-17,共6页International Journal of Stomatology

基　　金：吉林省科技厅科技发展计划国际合作项目(2018041405-3GH);吉林省科技厅自然科学基金(20190201058JC);吉林省财政厅科技项目(JCSZ2019378-1)。

摘　　要：牙周炎是发生在牙周组织的慢性感染性疾病,其发病机制及对全身系统疾病的影响一直是学术界关注的热点问题。许多学者认为,牙周炎不仅是一种常见的口腔疾病,更是全身疾病的潜在危险因素之一,但是目前关于牙周炎诱发全身系统疾病的具体机制尚不明确,可能与牙周致病菌、炎症因子及内质网应激等有关。近年来的研究发现,内质网应激是介导细胞凋亡的重要通路之一,并且与全身疾病密切相关。有研究显示,内质网应激在牙周炎诱导全身疾病过程中存在调控作用,但是目前关于内质网应激在牙周炎影响全身疾病过程中的作用研究较少,需要进一步探索。本文就内质网应激在牙周炎影响全身系统疾病中的研究进展进行综述,旨在探究牙周炎和全身系统疾病的内在联系,以期为牙周炎与其相关全身系统疾病的防治提供新的思路。Periodontitis is a chronic infectious disease that occurs in periodontal tissues,and its pathogenesis and effects on the system have been a hot issue in academic circles.Many scholars have shown that periodontitis is not only a common oral disease,but also a potential risk factor for systemic diseases.However,the mechanism of systemic diseases induced by periodontal disease is still unclear,which may be related to periodontal pathogens,inflammatory factors and endoplasmic reticulum stress.In recent years,studies have found that endoplasmic reticulum stress is an important pathway that mediates apoptosis and is closely related to systemic diseases.Some studies have shown that endoplasmic reticulum stress plays a regulatory role in the process of systemic diseases induced by periodontitis.However,few studies on the role of endoplasmic reticulum stress in periodontitis affecting systemic diseases have been found,and further exploration is needed.This article reviews the research progress of endoplasmic reticulum stress in periodontitis affecting systemic diseases and aims to explore the internal relationship between periodontitis and systemic diseases and provide new ideas for the prevention and treatment of periodontitis and its related systemic diseases.

关 键 词：牙周炎 内质网应激 全身疾病 

分 类 号：R782.2[医药卫生—口腔医学]