N-乙酰基转移酶10的研究进展  

Research advances on the function of N-acetyltransferase 10

作　　者：郭向飞 郝颖 赵烨 史海水 GUO Xiangfei;HAO Ying;ZHAO Ye;SHI Haishui(Neuroscience Research Center,Hebei Medical University,Shijiazhuang 050017,China)

机构地区：[1]河北医科大学神经科学研究中心,石家庄050017

出　　处：《生命的化学》2020年第11期2014-2019,共6页Chemistry of Life

基　　金：国家自然科学基金项目(81771462);三三三人才培养资助项目(YZRCPY333)。

摘　　要：N-乙酰基转移酶10(N-acetyltransferase 10,NAT10)是一种具有乙酰基转移酶作用的核蛋白,可催化组蛋白、非组蛋白发生乙酰化修饰。NAT10催化的非组蛋白乙酰化修饰在端粒酶活性调节、核糖体RNA的合成、DNA损伤修复、mRNA稳定性的维持等多种生命活动中扮演了重要角色,与癌症、Hutchinson-Gilford早衰综合征的发生、发展和预后密切相关。本文将从NAT10的结构与定位、生物学功能及其在疾病中的作用进行综述,以期为NAT10的相关研究提供参考。N-acetyltransferase 10(NAT10)is a nuclear protein with the function of acetyltransferase,which can catalyze acetylation modification of histones and nonhistone proteins.Nonhistone acetylation modification catalyzed by NAT10 plays an important role in various life activities such as regulation of telomerase activity,synthesis of ribosomal RNA,repair of DNA damage,and maintenance of mRNA stability.It is closely associated with the occurrence,development and prognosis of cancers and Hutchinson-Gilford Progeria Syndrome.In this article,we review the structure,localization,and biological function of NAT10,and its roles played in diseases,in order to provide a reference for the related studies of NAT10.

关 键 词：N-乙酰基转移酶10 N4-乙酰胞苷修饰 癌症 Hutchinson-Gilford早衰综合征 

分 类 号：R363[医药卫生—病理学]