DNA去甲基化在恶性肿瘤中的研究进展  

Research progress of DNA demethylation in malignant tumors

作　　者：刘文静 王舒婕 张巧 杨哲[1] LIU Wenjing;WANG Shujie;ZHANG Qiao;YANG Zhe(Department of Pathology,First Affilliated Hospital of Kunming Medical University,Kunming 650032,China;Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Kunming Medical University,Kunming 650500,China)

机构地区：[1]昆明医科大学第一附属医院病理科,昆明650032 [2]昆明医科大学基础医学院生物化学与分子生物学系,昆明650500

出　　处：《生命的化学》2020年第11期2035-2042,共8页Chemistry of Life

基　　金：国家自然科学基金项目(81660135,81560037,31960145);云南省科技厅应用基础研究面上项目(2019FB091,2018FB120);云南省科技厅—昆明医科大学联合专项项目[2017FB(-141),2017FE468(-132)]。

摘　　要：DNA去甲基化是一种将甲基化胞嘧啶转化为未修饰的胞嘧啶的过程,在表观遗传学上属于DNA甲基化的逆过程。DNA去甲基化可"复活"相关沉默基因,通过参与调控抑癌通路等方式起到抗肿瘤作用,是潜在的恶性肿瘤治疗靶点。本文就近年来DNA去甲基化在恶性肿瘤发生发展过程中的研究进展进行综述,阐述了肿瘤基础层次及临床应用中,去甲基化研究的现状,指出了当前存在的问题,旨在为抗肿瘤机制以及恶性肿瘤靶向治疗研究提供参考。DNA demethylation is the process which transforms methylated cytosine into unmodified cytosine,it is an epigenetic reversal procedure of DNA methylation.DNA demethylation plays an antitumor role by"resurrecting"related silencing genes and participating in the regulation of tumor suppressor pathways,which exhibits the potential of DNA demethylation as a target for malignant tumors treatment.This review introduces the research progress of DNA demethylation in the development of malignant tumors in recent years,expounds the current situation of fundamental research and clinical application of demethylation in malignant tumors,and points out the existing problems to provide reference for the research of anti-tumor mechanism and targeted therapy of malignant tumors.

关 键 词：DNA去甲基化 恶性肿瘤 去甲基化药物 

分 类 号：R730.2[医药卫生—肿瘤]