新疆区域雌激素水平和雌激素受体与胆道结石发病机制的相关性研究  

Correlation between pathogenesis of biliary calculi in Xinjiang region with estrogen level and estrogen receptor positivity rates

作　　者：阿扎提江·艾尼瓦尔 麦麦提依明·买买吐尔逊 玉苏甫[1] 于文庆[1] 克力木[1] Azhatijiang·Ainiwaer;Maimaitiyiming·Maimaituerxun;Yusufu null;Yu Wenqing;Kelimu null(Department of Minimally Invasive Surgery,Hernia and Abdominal Wall Surgery,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院微创疝腹壁外科,乌鲁木齐830001

出　　处：《中华肝胆外科杂志》2020年第12期925-928,共4页Chinese Journal of Hepatobiliary Surgery

基　　金：新疆维吾尔自治区自然科学基金(2017D01C095)。

摘　　要：目的探讨新疆区域雌激素水平和雌激素受体与胆道结石发病机制的相关性。方法回顾性分析2017年1月至2019年9月在新疆维吾尔自治区人民医院微创疝腹壁外科收治的胆道结石患者资料。胆道结石患者(结石组)共186例,男性59例,年龄(49.88±12.29)岁,女性127例,年龄(50.35±13.54)岁。女性患者中育龄期62例,年龄(42.50±5.33)岁;绝经后患者65例,年龄(58.56±8.74)岁。选取同期在新疆维吾尔自治区人民医院接受健康体检的无胆道结石者186例(对照组),其中男性57例,年龄(49.93±12.19)岁,女性129例,年龄(45.64±13.34)岁。女性健康体检人群中育龄期69例,年龄(37.76±7.53)岁;绝经后60例,年龄(54.87±6.51)岁。所有入组人员于8~10时空腹抽取静脉血3~5 ml,女性育龄期患者均取黄体中期静脉血。检测并对比结石组男性患者和对照组男性、育龄期和绝经胆道结石患者与相应对照组女性、单发结石与多发结石患者的促黄体生成素、雌二醇、卵泡刺激素、睾酮、孕酮、催乳素等指标。结石组患者取胆囊组织切片采用免疫组化(SP法)检测雌激素受体α、雌激素受体β阳性表达情况。结果结石组患者和对照组人群的性别、年龄、民族分布、合并疾病及体质量指数等差异无统计学意义(P>0.05)。男性胆道结石患者与对照组男性比较,雌二醇[(39.56±17.2)pg/ml比(20.86±13.57)pg/ml,t=2.250]、促黄体生成素[(5.72±3.74)mIU/ml比(2.75±2.53)mIU/ml,t=2.137]升高,差异有统计学意义(P<0.05),卵泡刺激素、催乳素、睾酮、孕酮水平差异无统计学意义(P>0.05)。与对照组女性相比,结石组女性患者的促黄体生成素、卵泡刺激素、催乳素、睾酮、孕酮水平差异无统计学意义(P>0.05),雌二醇水平升高[育龄期(64.69±24.00)pg/ml比(96.81±42.88)pg/ml,t=2.056,绝经后(32.80±26.51)pg/ml比(46.91±37.97)pg/ml,t=4.283],差异有统计学意义(P<0.05)。多发结石患者与单发结石患者比较Objective To study the correlation between pathogenesis of biliary calculi in Xinjiang region with estrogen levels and estrogen receptor positivity rates.Methods A retrospective study was conducted on patients with biliary calculi who were treated at the Department of Minimally Invasive Hernia Abdominal Wall Surgery,the People's Hospital of Xinjiang Uygur Autonomous Region from January 2017 to September 2019.There were 186 patients with biliary calculi(the stone group),including 59 male and 127 females,aged(49.88±12.29)and(50.35±13.54)years old.For female patients,62 were in childbearing age,aged(42.50±5.33)years;and 65 were postmenopausal woem,aged(58.56±8.74)years.In the same study period,186 patients who had no biliary calculi and who underwent physical examination at the People's Hospital of Xinjiang Uygur Autonomous Region were included into this study to form the control group.There were 57 males,aged(49.93±12.19)years,and 129 females,aged(45.64±13.34)years.Among females in the control group,69 were in childbearing age,aged(37.76±7.53)years and 60 were postmenopausal women,aged(54.87±6.51)years.Venous blood of 3 to 5ml were taken from all the study participants on an empty stomach from 8 to 10am.Mid-luteal venous blood was taken from female patients of childbearing age.The levels of luteinizing hormone,estradiol,follicle stimulating hormone,testosterone,progesterone,prolactin and other indicators were compared with the stone group male patients and the control group male,the biliary tract stone patients of childbearing age and the menopause and corresponding control group female.In the stone group,gallbladder tissue sections were taken and immunohistochemistry(SP method)was used to detect positive expressions of estrogen receptorαand estrogen receptorβ.Results There were no significant differences in gender,age,ethnic group distribution,comorbid diseases and body mass index between the stone group and the control group(P>0.05).Comparing male patients with biliary stones with men in the control gro

关 键 词：胆石 受体 雌激素 促黄体生成素 

分 类 号：R575.7[医药卫生—消化系统]