Asymmetric Catalytic[3+2]Annulation of Donor-Acceptor Cyclopropane with Cyclic Ketones:Facile Access to Enantioenriched 1-Oxaspiro[4.5]decanes  

作　　者：Zhong-Bo Zheng Wen-Fu Cheng Lijia Wang Jun Zhu Xiu-Li Sun Yong Tang 

机构地区：[1]The State Key Laboratory of Orgonometallic Chemistry,Shanghai Institute of Organic Chemistry,CAS,University of Chinese Academy of Sciences,345 Lingling Lu,Shanghai 200032,China [2]Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development,Department of Chemistry,East China Normal University,3663 North Zhongshan Road,Shanghai 200062,China

出　　处：《Chinese Journal of Chemistry》2020年第12期1629-1634,共6页中国化学（英文版）

基　　金：We thank the NSFC(Nos.91956103,21772224);the CAS(Nos.QYZDY-SSW-SLH016,XDB20000000);the STCSM(No.17JC1401200)for the financial support.

摘　　要：of main observation and conclusion A copper catalyzed enantioselective[3+2]annulation of donor-acceptor cyclopropanes with cyclic ketones has been developed,providing a concise protocol to enantioenriched l-oxaspiro[4.5]decanes in up to 98%yield with up to>99/1 dr and up to 92%ee.In addition,this method also provides a facile access to the enantioselective desymmetrisation of various 4-substituted cyclohexanones.The resulting products were easily converted to the core structures of two natural products Heliespirones A and halogenated sesquiterpene isolated from L saitoi.

关 键 词：SPIRO CATALYTIC substituted 

分 类 号：O62[理学—有机化学]