CASPR2抗体相关的Isaacs综合征1例  

Isaacs syndrome with CASPR2 antibody:A case report

作　　者：张凌峰 刘彬[1] ZHANG Lingfeng;LIU Bin(Department of Geriatric Neurology,First Affiliated Hospital of Kunming Medical University,Kunming 650000,China)

机构地区：[1]昆明医科大学第一附属医院老年神经内科,昆明650000

出　　处：《临床与病理杂志》2020年第12期3317-3319,共3页Journal of Clinical and Pathological Research

摘　　要：Isaacs综合征是一种因周围神经过度兴奋引起的疾病,其特征是广泛的肌肉颤搐和僵硬。最近的研究显示CASPR2抗体可能是Isaacs综合征的致病性抗体之一。现将笔者2019年在昆明医科大学第一附属医院遇到的1例CASPR2抗体阳性的以肌肉疼痛为主要表现的Isaacs综合征报告如下。Isaacs syndrome is a disease of peripheral nerve hyperexcitability,characterized by widespread muscle twitching and stiffness.More recent evidence suggests that CASPR2 antibody may be one of the pathogenic autoantibodies in Isaacs syndrome.We report a case of Isaacs syndrome with muscle pain as the main clinical manifestation and positive CASPR2 antibody from First Affiliated Hospital of Kunming Medical University in 2019.

关 键 词：ISAACS综合征 CASPR2抗体 肌肉疼痛 

分 类 号：R746[医药卫生—神经病学与精神病学]