复发性上皮性卵巢癌的治疗研究进展  

作　　者：刘菲婷 孟凡良[2] 

机构地区：[1]南方医科大学第一临床医学院,广州510515 [2]南方医科大学南方医院妇产科

出　　处：《妇产与遗传（电子版）》2020年第4期45-49,共5页Obstetrics-Gynecology and Genetics (Electronic Edition)

基　　金：国家自然科学基金青年科学基金项目(81402127);2019年南方医院院级教育研究课题(19NJ-ZDPY09);南方医科大学2020年度大学生创新创业训练计划项目(X202012121185)。

摘　　要：卵巢癌是最常见的妇科恶性肿瘤之一,死亡率居妇科肿瘤第一位。上皮性卵巢癌占所有卵巢癌的80%~90%,其中多达75%的病例在诊断时已到晚期,虽然部分病例可以通过肿瘤细胞减灭术和以铂类药物为基础的化疗达到完全临床缓解,但是大约70%的晚期上皮性卵巢癌患者会在完成初级治疗后的18~28个月复发。虽然复发性卵巢癌患者经过治疗后可以有较长的生存期,但复发性上皮性卵巢癌由于不能治愈,只有20%~40%的患者生存期超过5年。针对复发性上皮性卵巢癌,目前的治疗方案主要有手术治疗、化学治疗、生物治疗和靶向治疗等。近年来,随着对卵巢癌发病机制研究的不断深入,对复发卵巢癌的治疗也出现了较大的进展,例如抗血管生成药物及聚腺苷二磷酸核糖聚合酶抑制剂等新的靶向治疗方法,这些新型药物的出现为复发性卵巢癌患者的治疗提供了可能,有助于延长患者的生存期。本文将对复发性上皮性卵巢癌的化疗研究进展作一综述,希望为复发性妇科恶性肿瘤的治疗提供一定的借鉴。Ovarian cancer is one of the most common gynecological malignancies,ranking first in the mortality rate of gynecological tumors.Epithelial ovarian cancer accounts for about 80%~90%of all ovarian cancers.As many as 75%of the cases are diagnosed as advanced stage although some cases could achieve complete clinical remission through cytoreductive surgery in combination with platinum-based chemotherapy.However,approximately 70%of advanced epithelial ovarian cancer will relapse within 18 to 28 months after completing primary comprehensive treatment.Although patients with recurrent ovarian cancer can have a longer survival period after treatment,but recurrent epithelial ovarian cancer cannot be cured,only 20%~40%of patients survive for more than 5 years.For recurrent epithelial ovarian cancer,current treatment options mainly include surgery,chemotherapy,biological therapy,and targeted therapy.In recent years,with the continuous indepth research on the pathogenesis of ovarian cancer,the treatment of recurrent ovarian cancer has also made great progress,such as anti-angiogenesis drugs and polyadenosine diphosphate ribose polymerase(PARP)inhibitors.The emergence of these new drugs provides the possibility for the treatment of patients with recurrent ovarian cancer and helps prolong the survival of patients.This article will review the research progress of chemotherapy for recurrent epithelial ovarian cancer,hoping to provide some references for the treatment of recurrent gynecological malignancies.

关 键 词：复发性上皮性卵巢癌 化学治疗 无进展生存期 

分 类 号：R737.33[医药卫生—肿瘤]