复方苁蓉益智胶囊致肝损伤  

Liver injury induced by compound Congrong Yizhi capsules(复方苁蓉益智胶囊)

作　　者：牛晓强[1] 程林忠[1] Niu Xiaoqiang;Cheng Linzhong(Department of Pharmacy,Heping Hospital Affiliated to Changzhi Medical College,Shanxi Province,Changzhi 046000,China)

机构地区：[1]长治医学院附属和平医院药剂科,山西省长治市046000

出　　处：《药物不良反应杂志》2020年第12期693-694,共2页Adverse Drug Reactions Journal

摘　　要：1例48岁女性患者因记忆力下降口服复方苁蓉益智胶囊1.2 g(4粒),3次/d。约20 d后,患者出现恶心,纳差,尿黄和皮肤、巩膜黄染。停用复方苁蓉益智胶囊。停药7 d后,实验室检查:丙氨酸转氨酶(ALT)1349 U/L,天冬氨酸转氨酶(AST)827 U/L,碱性磷酸酶(ALP)156 U/L,总胆红素(TBil)213.7μmol/L,考虑为复方苁蓉益智胶囊致肝损伤。给予还原型谷胱甘肽、复方甘草酸苷、丁二磺酸腺苷蛋氨酸、地塞米松等药物治疗。患者食欲逐渐改善,黄疸逐渐消退。治疗36 d后复查:ALT 26 U/L,AST 30U/L,ALP 86U/L,TBil 27.2μmol/L。考虑患者的肝损伤与复方苁蓉益智胶囊中的制何首乌有关。A 48‑year‑old female patient received compound Congrong Yizhi capsules 1.2 g(4 capsules)orally thrice daily for memory decline.About 20 days later,the patient developed nausea,anorexia,yellow urine,and yellow staining of skin and sclera.Compound Congrong Yizhi capsules were discontinued.Seven days after drug withdrawal,laboratory tests showed that alanine aminotransferase(ALT)was 1349 U/L,aspartate aminotransferase(AST)was 827 U/L,alkaline phosphatase(ALP)was 156 U/L,and total bilirubin(TBil)was 213.7μmol/L.Liver injury induced by compound Congrong Yizhi capsules was considered.Reduced glutathione,compound glycyrrhizin,ademetionine 1,4‑butanedisulfonate,and dexamethasone were given.The patient′s appetite was gradually improved and jaundice gradually subsided.After 36 days of treatments,ALT was 26 U/L,AST was 30 U/L,ALP was 86 U/L,and TBil was 27.2μmol/L.The liver injury of the patient was considered to be related to Radix Polygoni Multiflori Preparata(prepared fleeceflower root)in compound Congrong Yizhi capsules.

关 键 词：化学和药物性肝损伤 何首乌属 植物 药用 

分 类 号：R575[医药卫生—消化系统]