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作 者:Lan Chen Donghui Wang Jiajun Qiu Xianming Zhang Xingdan Liu Yuqin Qiao Xuanyong Liu
机构地区:[1]State Key Laboratory of High Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai,200050,China [2]Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences,Beijing,100049,China [3]School of Materials Science and Engineering,Hebei University of Technology,Tianjin,300130,China [4]School of Chemistry and Materials Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou,310024,China
出 处:《Bioactive Materials》2021年第1期191-207,共17页生物活性材料(英文)
基 金:the National Natural Science Foundation of China(51831011 and 31570973);National Science Foundation for Distinguished Young Scholars of China(51525207);Science and Technology Commission of Shanghai Municipality(19JC1415500,17441904000,and 18YF1426900)are acknowledged.
摘 要:Ds-block elements have been gaining increasing attention in the field of biomaterials modification,owing to their excellent biological properties,such as antibiosis,osteogenesis,etc.However,their function mechanisms are not well understood and conflicting conclusions were drawn by previous studies on this issue,which are mainly resulted from the inconsistent experimental conditions.In this work,three most widely used ds-block elements,copper,zinc,and silver were introduced on titanium substrate by plasma immersion ion implantation method to investigate the rule of ds-block elements in the immune responses.Results showed that the implanted samples could decrease the inflammatory responses compared with Ti sample.The trend of anti-inflammatory effects of macrophages on samples was in correlation with cellular ROS levels,which was induced by the implanted biomaterials and positively correlated with the number of valence electrons of ds-block elements.The co-culture experiments of macrophages and bone marrow mesenchymal stem cells showed that these two kinds of cells could enhance the anti-inflammation and osteogenesis of samples by the paracrine manner of PGE2.In general,in their steady states on titanium substrate(Cu2+,Zn2+,Ag),the ds-block elements with more valence electrons exhibit better anti-inflammatory and osteogenic effects.Moreover,molecular biology experiments indicate that the PGE2-related signaling pathway may contribute to the desired immunoregulation and osteoinduction capability of ds-block elements.These findings suggest a correlation between the number of valence electrons of ds-block elements and the relevant biological responses,which provides new insight into the selection of implanted ions and surface design of biomaterials.
关 键 词:Ds-block element Valence electron Immune response OSTEOIMMUNOLOGY Molecular mechanism
分 类 号:R318[医药卫生—生物医学工程]
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