术前淋巴细胞与血小板、中性粒细胞和单核细胞比值对非小细胞肺癌病人预后的相关性研究  

The correlation study of preoperative platelet to lymphocyte ratio,neutrophil to lymphocyte ratio and lymphocyte to monocyte ratio on the prognosis of patients with non-small cell lung cancer

作　　者：戴宁凰 郑中锋 李威[1] 陆波[1] 庄淮千 DAI Ninghuang;ZHENG Zhongfeng;LI Wei(Department of Thoracic Surgery,Suqian People’s Hospital,Nanjing Gulou Hospital Group,Jiangsu,Suqian 223380,China)

机构地区：[1]南京鼓楼医院集团宿迁市人民医院胸外科,223380

出　　处：《临床外科杂志》2020年第11期1020-1024,共5页Journal of Clinical Surgery

基　　金：2017年江苏省卫生计生委医学科研课题(Z201701)。

摘　　要：目的评估术前外周血血小板与淋巴细胞比值(PLR)、中性粒细胞与淋巴细胞比值(NLR),淋巴细胞与单核细胞比值(LMR)对非小细胞肺癌(NSCLC)病人预后的预测价值。方法2013年1月~2015年1月我院收治的NSCLC病人120例,均行手术治疗。通过受试者工作特征(ROC)曲线确定PLR、NLR、LMR临界值,比较不同组间的临床病理特征,分析影响NSCLC病人预后影响因素。结果PLR、NLR、LMR与NSCLC病人总生存期(OS)相关性ROC曲线下面积(AUC)分别为0.706(95%CI:0.616~0.785)、0.617(95%CI:0.523~0.704)、0.658(95%CI:0.565~0.742),临界值分别为128.87、3.30和3.93。Cox回归分析显示,年龄(HR:2.074,95%CI:0.760~2.669,P=0.036),TNM分期(HR:2.264,95%CI:1.054~4.862,P=0.036),PLR(HR:2.964,95%CI:1.003~8.762,P=0.049)是影响NSCLC病人OS的独立危险因素,年龄(HR:1.829,95%CI:1.031~3.246,P=0.039),TNM分期(HR:1.883,95%CI:1.065~3.329,P=0.030)是影响病人无病生存期(DFS)的独立危险因素。结论术前PLR对NSCLC病人预后的预测价值优于NLR、LMR,或可作为预后的参考指标。Objective To assess the prognosis of patients with non-small cell lung cancer(NSCLC) by the ratio of platelet to lymphocyte ratio(PLR),neutrophil to lymphocyte ratio(NLR) and lymphocyte to monocyte ratio(LMR) before operation value.Methods 120 patients with NSCLC who underwent surgical treatment in Suqian People’s Hospital of Nanjing Gulou Hospital Group from January 2013 to January 2015 were selected.The receiver operating characteristic(ROC) curve was used to determine the critical values of PLR,NLR,and LMR,to compare the clinicopathological characteristics between different groups,and to analyze the factors affecting the prognosis of NSCLC patients.Results The area under the ROC(AUC) of PLR,NLR,LMR and NSCLC patients’ overall survival(OS) was 0.706(95%CI:0.616~0.785),0.617(95%CI:0.523~0.704),0.658(95%CI:0.565~0.742),the critical values are 128.87,3.30,and 3.93,respectively.Cox regression analysis showed that age(HR:2.074,95%CI:0.760~2.669,P=0.036),TNM stage(HR:2.264,95%CI:1.054~4.862,P=0.036),PLR(HR:2.964,95%CI:1.003~8.762,P=0.049) are independent risk factors that affect the OS of NSCLC patients,age(HR:1.829,95%CI:1.031~3.246,P=0.039),TNM stage(HR:1.883,95%CI:1.065~3.329,P=0.030) was an independent risk factor affecting the disease-free survival(DFS) of patients.Conclusion The predictive value of preoperative PLR for the prognosis of NSCLC patients is better than that of NLR and LMR,or it can be used as a prognostic index.

关 键 词：非小细胞肺癌 血小板与淋巴细胞比值 中性粒细胞与淋巴细胞比值 淋巴细胞与单核细胞比值 预后 

分 类 号：R734.2[医药卫生—肿瘤]