亚甲蓝荧光在早期乳腺癌前哨淋巴结定位的临床价值  

The clinical value of intraoperative methylene blue near-infrared fluorescence imaging and mapping in the sentinel lymph node biopsy of the early stage breast cancer

作　　者：田少林 陈波[1] TIAN Shaolin;CHEN Bo(Department of thyroid&breast of Hubei Maternal and Children’s Hospital,Wuhan,430070,China)

机构地区：[1]湖北省妇幼保健院甲乳外科,武汉430070

出　　处：《临床外科杂志》2020年第11期1025-1027,共3页Journal of Clinical Surgery

摘　　要：目的观察亚甲蓝荧光在早期乳腺癌前哨淋巴结定位的临床价值。方法 2018年1月~2019年12月收治的早期乳腺癌(cT1-2N0M0)病人79例,按入院顺序分为对照组和观察组。对照组39例,采用术中单用亚甲蓝染色定位前哨淋巴结,观察组40例,采用术中亚甲蓝荧光双示踪定位前哨淋巴结,比较两组病人活检结果和手术相关指标。结果两组病人手术均能成功检出前哨淋巴结,检出率均为100%。观察组检出淋巴结数小于对照组,手术时间少于对照组,差异有统计学意义(P<0.05)。两组术中出血量、手术切口并发症(切口感染/裂开、切口积液)比较,差异无统计学意义(P>0.05)。结论早期乳腺癌前哨淋巴结活检采用术中亚甲蓝荧光示踪定位相较于亚甲蓝单染料定位,手术操作更直观、简便、高效。Objective:To observe the clinical value of intraoperative methylene blue(MB)nearinfrared fluorescence imaging and mapping in the sentinellymph node biopsy(SLNB)of early stage breast cancer.Methods:The clinical datas of 79 patients of early stage breast cancer(cT1-2N0M0)who were admitted from January 2018 to December 2019 in the department of thyroid&breast of Hubei Maternal and Children’s Hospital were analyzed retrospectively.These cases were divided into two groups according to admission orders:control group(A)and observation group(B).Group A(39 cases)were applied by intraoperative MB mapping of SLNs.Group B(40 cases)were applied by intraoperative MB near-infrared fluorescence imaging and mapping of SLNs.To compare the biopsy results and surgical indicators of the two groups.Results:The two groups of SLNB success rates were 100%.There were significant differences in the aspects of the numbers lymph nodes detected and the operation time of the two groups(P<0.05).The mean operation time of the observation group(B)was less than the control group(A).The mean numbers of the lymph nodes detected in observation group(B)were less than the control group(A).There were no significant differences in the aspects of the intraoperative blood loss,surgical incision complications(such as incision infection/dehiscence,incision hydrops)of the two groups(P>0.05).Conclusion:Compared with simple MB mapping,the application by intraoperative MB near-infrared fluorescence imaging and mapping was more intuitive,simple,efficient for SLNB of the early stag breast cancer and there was high clinical value for it.

关 键 词：亚甲蓝 荧光 乳腺癌 前哨淋巴结 活检 

分 类 号：R737.9[医药卫生—肿瘤]