膀胱肿瘤抗原、尿脱落细胞学、泌尿系CT联合检查在上尿路上皮肿瘤诊断中的价值  

The value of bladder tumor antigen,exfoliative cytology and urinary CT in the diagnosis of upper urinary tract urothelial carcinoma

作　　者：凌生涛 姚启盛 杨二江 黄力 LING Shengtao;YAO Qisheng;YANG Erjiang(Department of Urology,Taihe Hospital,Hubei Medical College,Hubei,Shiyan 442000,China)

机构地区：[1]湖北省十堰市太和医院/湖北医药学院附属医院泌尿外科,442000

出　　处：《临床外科杂志》2020年第11期1063-1065,共3页Journal of Clinical Surgery

基　　金：湖北省卫生健康委资助项目(WJ2019M060);湖北省十堰市太和医院资助项目(2016JJXM072)。

摘　　要：目的探讨尿膀胱肿瘤抗原(BTA)、尿脱落细胞学、泌尿系CT联合检查在上尿路上皮肿瘤诊断中的价值。方法2018年9月~2020年5月我院就诊的疑似上尿路上皮肿瘤病人51例,在行输尿管镜检或手术治疗前分别行尿BTA、尿脱落细胞学、泌尿系CT检查,并行相关性分析。结果尿BTA的敏感度(80.00%)和泌尿系CT的敏感度(85.71%)均高于尿脱落细胞学(62.86%),但尿细胞学的特异度(93.75%)高于尿BTA(75.00%)和泌尿系CT(81.25%),差异有统计学意义(P<0.05)。三者联合检查后,其灵敏度、阴性预测值、诊断符合率均高于各单项检查,说明联合检查可提高上尿路上皮肿瘤检出率,且准确率高于各单项检查。且BTA敏感度随着肿瘤病理分级、分期的增加而增加。结论BTA在上尿路上皮肿瘤的诊断中具有较高的临床应用价值,BTA联合尿脱落细胞学和泌尿系CT检查可提高对上尿路上皮肿瘤检出率。Objective:This paper was to explore the value of combined examination of urinary bladder tumor antigen(BTA),urine exuviate cytology and urinary CT in the diagnosis of upper urinary tract urothelial carcinoma(UTUC).Methods:BTA test,Urinary exfoliative cytology and CT of the urinary system were performed on 51 patients who were suspected UTUC and admitted to our hospital from September 2018 to May 2020 were collected.Results:The sensitivity of urinary BTA(80.00%)and urinary CT(85.71%)was higher than that of urinary cytology(62.86%),but the specificity of urinary cytology(93.75%)was higher than that of urinary BTA(75.00%)and urinary CT(81.25%),and there were significant differences between each two groups(P<0.05).The sensitivity,negative predictive value and diagnostic coincidence rate of the combined tests were higher than those of each single test.And the BTA sensitivity increased along with the rise of pathological grade and stage of UTUC.Conclusion:BTA combined with exfoliative cytology and CT scan of urinary system improved the detection rate of UTUC and had high clinical value.

关 键 词：膀胱肿瘤抗原 尿液细胞学 泌尿系CT 上尿路上皮肿瘤 

分 类 号：R737.1[医药卫生—肿瘤]