中国乳腺癌专病队列研究:人群队列研究方法及基线特征  

The Breast Cancer Cohort Study in Chinese Women:the methodology of population-based cohort and baseline characteristics

作　　者：包鹤龄[1] 刘丽媛[2] 方利文[1] 丛舒 付振涛[3] 唐俊利[3] 杨珊[4] 史卫卫 范敏[6] 曹民权[6] 郭晓雷[3] 孙纪新[5] 耿翠芝[4] 段学宁[7] 余之刚[2] 王临虹[1] Bao Heling;Liu Liyuan;Fang Liwen;Cong Shu;Fu Zhentao;Tang Junli;Yang Shan;Shi Weiwei;Fan Min;Cao Minquan;Guo Xiaolei;Sun Jixin;Geng Cuizhi;Duan Xuening;Yu Zhigang;Wang Linhong(National Center for Chronic and Non-communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 100050,China;The Second Hospital of Shandong University,Ji’nan 250033,China;Shandong Center for Disease Control and Prevention,Ji’nan 250014,China;The Fourth Affiliated Hospital of Hebei Medical University,Shijiazhuang 050019,China;Hebei Provincial Center for Disease Control and Prevention,Shijiazhuang 050021,China;Taixing Center for Disease Control and Prevention,Taizhou 225400,China;Breast Disease Center,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]中国疾病预防控制中心慢性非传染性疾病预防控制中心,北京100050 [2]山东大学第二医院,济南250033 [3]山东省疾病预防控制中心,济南250014 [4]河北医科大学第四医院,石家庄050019 [5]河北省疾病预防控制中心,石家庄050021 [6]泰兴市疾病预防控制中心,泰州225400 [7]北京大学第一医院乳腺疾病中心,100034

出　　处：《中华流行病学杂志》2020年第12期2040-2045,共6页Chinese Journal of Epidemiology

基　　金：国家重点研发计划(2016YFC0901300,2016YFC0901301)。

摘　　要：目的乳腺癌在女性癌症中发病率第一且逐年上升。2016年9月,国家重点研发计划精准医学研究中国乳腺癌专病队列项目启动,旨在整合队列资源、提高随访质量、构建标准共享的乳腺癌专病队列,为实现乳腺癌发现、预防、早诊、治疗及预后研判等提供研究基础与标准化数据共享平台。方法本研究基于社区人群,采用询问调查、身体测量、生物样本采集、乳腺超声和钼靶X线检查建立前瞻性队列,采用区域健康监测和定向监测随访队列。结果整合乳腺癌专病社区人群队列112118人,其中完成55419人标准化队列调查,54304人采集生物样本。平均年龄51.7岁,超重/肥胖女性占62.7%,绝经女性占48.9%。结论本研究将为中国女性乳腺癌精准防治提供队列基础和研究平台。Objective Breast cancer has been the first cancer among women with the incidence increasing gradually.In September 2016,the Breast Cancer Cohort Study in Chinese Women(BCCS-CW)was initiated,aiming to establish a standardized and sharable breast cancer-specific cohort by integrating the existing cohort resource and improving the quality of follow-up.The BCCS-CW may provide a research basis and platform for the precision prevention and treatment of breast cancer in etiology identification,prevention,early diagnosis,treatment,and prognosis prediction.Methods We conducted a population-based perspective cohort by questionnaire interview,anthropometry,biological specimens,breast ultrasound and mammography.The cohort was followed by using regional health surveillance and ad hoc survey.Results Finally,BCCS-CW included 112118 women,in which 55419 women completed the standardized investigation and blood specimens were collected from 54304 women.The mean age of participants was 51.7 years old,62.7%were overweight or obese,and 48.9%were menopausal.Conclusion The BCCS-CW will provide population-based cohort resource and research platform for the precise prevention and treatment of breast cancer in Chinese women.

关 键 词：乳腺癌 队列 风险 

分 类 号：R737.9[医药卫生—肿瘤]