Polymyxin for the treatment of intracranial infections of extensively drug-resistant bacteria in children after neurosurgical operation  

作　　者：Jing Ye Lin-Hua Tan Zhi-Peng Shen Yun-Song Yu Deng-Ming Lai Jie Fan Qiang Shu 

机构地区：[1]Department of Surgical ICU,Children's Hospital,Zhejiang University School of Medicine,National Clinical Research Center For Child Health,Hangzhou 310052,China [2]Department of Neurosurgery,Children's Hospital,Zhejiang University School of Medicine,National Clinical Research Center For Child Health,Hangzhou 310052,China [3]Department of Infectious Diseases,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China [4]Department of Neonatal Surgery,Children's Hospital,Zhejiang University School of Medicine,National Clinical Research Center For Child Health,Hangzhou,Zhejiang,China [5]Department of Surgery,University of Pittsburgh School of Medicine,Pittsburgh,PA,USA [6]Research and Development,Veterans Affairs Pittsburgh Healthcare System,Pittsburgh,PA,USA [7]McGowan Institute for Regenerative Medicine,University of Pittsburgh,Pittsburgh,PA,USA [8]Department of Thoracic and Cardiovascular Surgery,Children's Hospital,Zhejiang University School of Medicine,National Clinical Research Center For Child Health,No.3333 Bin-Sheng Road,Bin-Jiang District,Hangzhou 310052,China

出　　处：《World Journal of Pediatrics》2020年第5期528-532,共5页世界儿科杂志（英文版）

基　　金：This study was supported by a grant from Education of Zhejiang Province Y201737787(JY)];National Natural Science Foundation of China 81901989(DML);Project funded by China Postdoctoral Science Foundation 2019M652108(DML).

摘　　要：Background Increased meningitis caused by extensively drug-resistant bacillary presents a significant challenge in antibiotic selection.The aim of our study was to evaluate the efficacy and safety of polymyxin in the treatment of post-neurosurgical meningitis due to the extensively drug-resistant bacillary in children.Methods We performed a retrospective study on post-neurosurgical meningitis caused by the extensively drug-resistant bacillary in children,who were treated with polymyxin for≥3 days.Results Among five post-neurosurgical meningitis cases that were included,the children were infected by Acinetobacter baumannii(n=3),Klebsiella pneumonia(n=l),and Pseudomonas aeruginosa(n=1).The drug susceptibility test showed that they were extensively drug-resistant bacillary.Two patients received intravenous polymyxin E.Three children received intravenous combined with intraventricular injection of polymyxin B.One patient infected by Klebsiella pneumonia eventually died of septic shock.No serious adverse effects of polymyxin were observed.Conclusions Polymyxin is a safe and effective therapy for post-neurosurgical,multidrug-resistant bacillary meningitis in children.

关 键 词：Drug resistance MENINGITIS Neurosurgical procedures POLYMYXIN 

分 类 号：R726.5[医药卫生—儿科]