POLYMYXIN

作品数：23被引量：27H指数：2
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相关领域：医药卫生生物学更多>>
相关作者：钱朝东唐瑜蒋晓飞更多>>
相关机构：复旦大学浙江大学上海市胸科医院上海市第一妇婴保健院更多>>
相关期刊：《Asian pacific Journal of Reproduction》《World Journal of Gastrointestinal Surgery》《World Journal of Clinical Cases》《Infectious Microbes & Diseases》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金更多>>
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Observation of Two Novel mcr-10.1–Carrying Plasmids in Clinical Escherichia coli Strains
《Infectious Microbes & Diseases》2024年第4期206-209,共4页Zhaopeng Liu Xinrou Zheng Congcong Nan Jihua Xu Jiaming Zhu Ling Li Mingyu Wang Wenjia Wang Wenlong Shen 
Polymyxins are a class of last-resort antibiotics used to treat infections caused by multidrug-resistant bacteria. Mobile resistance determinants for polymyxins, including mcr-1 to mcr-10 genes, have previously been r...
关键词：POLYMYXIN Escherichia coli mcr-10 anal fistula PLASMID antimicrobial resistance antibiotic resistance gene 
Enhancement of polymyxin B1 production by an artificial microbial consortium of Paenibacillus polymyxa and recombinant Corynebacterium glutamicum producing precursor amino acids被引量：1
《Synthetic and Systems Biotechnology》2024年第1期176-185,共10页Hui-Zhong Sun Si-Yu Wei Qiu-Man Xu Wei Shang Qing Li Jing-Sheng Cheng Ying-Jin Yuan 
grateful for the financial supports from the National Key R&D Program of China(2018YFA0902200);the National Natural Science Foundation of China(Program:21878224).
Polymyxin B,produced by Paenibacillus polymyxa,is used as the last line of defense clinically.In this study,exogenous mixture of precursor amino acids increased the level and proportion of polymyxin B1 in the total of...
关键词：POLYMYXIN CO-CULTURE Paenibacillus polymyxa Corynebacterium glutamicum Medium optimization Metabolic precursors 
Polymyxin sensitivity/resistance cosmopolitan status,epidemiology and prevalence among O1/O139 and non-O1/non-O139 Vibrio cholerae:A meta-analysis
《Infectious Medicine》2023年第4期283-293,共11页Bright E.Igere Hope Onohuean Declan C.Iwu Etinosa O.Igbinosa 
funds provided by African German Network of Excellence in Science 2022 (AGNES-2022).
Resistance/sensitivity to polymyxin-B(PB)antibiotic has been employed as one among other epidemiologically relevant biotyping-scheme for Vibrio cholerae into Classical/El Tor biotypes.However,recent studies have re-ve...
关键词：Biotyping scheme Environmental nonO1/nonO139 V.cholerae Clinical O1/O139 V.cholerae PB-sensitive/PB-resistant strains Global epidemiological relevance Polymyxin B 
Polymyxin resistance caused by large-scale genomic inversion due to IS26 intramolecular translocation in Klebsiella pneumoniae被引量：1
《Acta Pharmaceutica Sinica B》2023年第9期3678-3693,共16页Haibin Li Lang Sun Han Qiao Zongti Sun Penghe Wang Chunyang Xie Xinxin Hu Tongying Nie Xinyi Yang Guoqing Li Youwen Zhang Xiukun Wang Zhuorong Li Jiandong Jiang Congran Li Xuefu You 
supported by the National Natural Science Foundation of China(32141003);the CAMS Innovation Fund for Medical Sciences(CIFMS)(2021-I2M-1-030,2021-I2M-1-039,China);the Fundamental Research Funds for the Central Universities(2021-PT350-001,China);the National Science and Technology Infrastructure of China(NPRC-32)。
Polymyxin B and polymyxin E(colistin)are presently considered the last line of defense against human infections caused by multidrug-resistant Gram-negative organisms such as carbapenemase-producer Enterobacterales,Aci...
关键词：Klebsiella pneumoniae Polymyxin resistance mgrB IS26 Whole genome sequencing Structural variation INVERSION 
LPS adsorption and inflammation alleviation by polymyxin B-modified liposomes for atherosclerosis treatment被引量：2
《Acta Pharmaceutica Sinica B》2023年第9期3817-3833,共17页Huiwen Liu Honglan Wang Qiyu Li Yiwei Wang Ying He Xuejing Li Chunyan Sun Onder Ergonul Fusun Can Zhiqing Pang Bo Zhang Yu Hu 
supported by the National Natural Science Foundation of China(82070228,81773283);the National Key R&D Program of China(No.2019YFC1316204)。
Chronic inflammation is critical in the onset and progression of atherosclerosis(AS).The lipopolysaccharide(LPS)level in the circulation system is elevated in AS patients and animal models,which is correlated with the...
关键词：LIPOPOLYSACCHARIDE ATHEROSCLEROSIS POLYMYXIN Liposomes MACROPHAGES 
Prevalence of polymyxin-induced nephrotoxicity and its predictors in critically ill adult patients:A meta-analysis
《World Journal of Clinical Cases》2022年第31期11466-11485,共20页Jiang-Lin Wang Bi-Xiao Xiang Xiao-Li Song Rui-Man Que Xiao-Cong Zuo Yue-Liang Xie 
Supported by The Hunan Province Natural Science Foundation,No.2022JJ80043;Nature Science Foundation of Changsha,No.kq2014268;Hunan Engineering Research Center of Intelligent Prevention and Control for Drug Induced Organ Injury,No.40;Scientific Research Fund Project of Hunan Pharmaceutical Society,No.2020YXH010.
BACKGROUND Polymyxin-induced nephrotoxicity is a major safety concern in clinical practice due to long-term adverse outcomes and high mortality.AIM To conducted a systematic review and meta-analysis of the prevalence ...
关键词：Polymyxins NEPHROTOXICITY Critically ill adult patients Risk factors META-ANALYSIS 
Impact of Polymyxin Resistance on Virulence and Fitness among Clinically Important Gram-Negative Bacteria被引量：2
《Engineering》2022年第6期178-185,共8页Yuan Wang Qixia Luo Tingting Xiao Yunying Zhu Yonghong Xiao 
supported by the National Key Research and Development Program of China (2017YFC1600100 and2017YFC1200203);the National Natural Science Foundation of China (81702040);the National Science Foundation of Zhejiang Province,China (LY20H190002)
Humanity is facing an enormous and growing worldwide threat from the emergence of multi-drug-resistant(MDR)Gram-negative bacteria such as Escherichia coli,Klebsiella pneumoniae,and Acinetobacter baumannii.Polymyxin B ...
关键词：POLYMYXIN RESISTANCE VIRULENCE FITNESS Gram-negative bacteria Acinetobacter baumannii Escherichia coli Klebsiella pneumoniae 
Expert Consensus on Polymyxin Antimicrobial Susceptibility Testing and Clinical Interpretation被引量：1
《Chinese Medical Sciences Journal》2021年第1期1-16,共16页Qiwen Yang Xiaoling Ma Fupin Hu Jing Zhang Tongwen Sun Baiyi Chen Yingchun Xu Youning Liu Chinese Committee on Antimicrobial Susceptibility Testing(ChiCAST) Expert Committee on Infectious Diseases,China Medical Education Association 
the National Key Research&Development Program(2018YFC1200100,2018YFC1200105);the Major Research and Development Project of Innovative Drugs,Ministry of Science and Technology of China(2017ZX09304005).
The polymyxins are important antimicrobial agents against antibiotic-resistant gram-negative bacilli.In 2020,the Clinical and Laboratory Standards Institute modified the clinical breakpoints for polymyxin susceptibili...
关键词：POLYMYXIN antimicrobial susceptibility testing clinical interpretation expert consensus 
Polymyxin for the treatment of intracranial infections of extensively drug-resistant bacteria in children after neurosurgical operation被引量：6
《World Journal of Pediatrics》2020年第5期528-532,共5页Jing Ye Lin-Hua Tan Zhi-Peng Shen Yun-Song Yu Deng-Ming Lai Jie Fan Qiang Shu 
This study was supported by a grant from Education of Zhejiang Province Y201737787(JY)];National Natural Science Foundation of China 81901989(DML);Project funded by China Postdoctoral Science Foundation 2019M652108(DML).
Background Increased meningitis caused by extensively drug-resistant bacillary presents a significant challenge in antibiotic selection.The aim of our study was to evaluate the efficacy and safety of polymyxin in the ...
关键词：Drug resistance MENINGITIS Neurosurgical procedures POLYMYXIN 
Polymyxin NP实验筛查肠杆菌科多黏菌素耐药菌株临床评价
《检验医学》2020年第10期994-999,共6页唐瑜 沈平华 史保庆 蒋晓飞 
国家自然科学基金资助项目(81871692);国家自然科学基金资助项目(81572031)。
目的评价Polymyxin NP实验筛查多黏菌素耐药肠杆菌科细菌的临床价值。方法采用Polymyxin NP实验对461株肠杆菌科临床分离株进行初步筛查,采用微量肉汤稀释法测定菌株对多黏菌素的最小抑菌浓度(MIC),采用纸片扩散法进行临床常用抗菌药物...
关键词：肠杆菌科 Polymyxin NP实验 多黏菌素耐药 
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