Observation of Two Novel mcr-10.1–Carrying Plasmids in Clinical Escherichia coli Strains  

作　　者：Zhaopeng Liu Xinrou Zheng Congcong Nan Jihua Xu Jiaming Zhu Ling Li Mingyu Wang Wenjia Wang Wenlong Shen 

机构地区：[1]Department of Anorectal Surgery,Qilu Hospital(Qingdao),Cheeloo College of Medicine,Shandong University,Qingdao,China [2]State Key Laboratory of Microbial Technology,Microbial Technology Institute,Shandong University,Qingdao,China [3]Yinan Hospital of Traditional Chinese Medicine,Yinan,China [4]School of Life Sciences,Shandong University,Qingdao,China

出　　处：《Infectious Microbes & Diseases》2024年第4期206-209,共4页感染微生物与疾病（英文）

摘　　要：Polymyxins are a class of last-resort antibiotics used to treat infections caused by multidrug-resistant bacteria. Mobile resistance determinants for polymyxins, including mcr-1 to mcr-10 genes, have previously been reported. Among them, mcr-10 has commonly beenobserved in Enterobacter and Klebsiella species. However, the presence of mcr-10 in Escherichia coli, an important opportunistic pathogen, has rarely been reported. This work describes the observation of mcr-10.1 in two clinical E. coli strains, with mcr-10.1 hosted ontwo novel plasmids, one of which carries transconjugation genes. These strains were isolated from anal fistula–suffering patients, suggesting their close relation to human bacterial infection. The genetic context of mcr-10.1 was also found to differ from those previouslyidentified in E. coli strains. This work is the first observation of mcr-10.1–carrying E. coli in clinical settings, expanding our knowledge ofthis important antibiotic resistance gene.

关 键 词：POLYMYXIN Escherichia coli mcr-10 anal fistula PLASMID antimicrobial resistance antibiotic resistance gene 

分 类 号：R378.21[医药卫生—病原生物学]