钙通道阻滞剂对牙龈组织细胞凋亡的影响及相关研究进展  

The Effect of Calcium Channel Blockers Induced Apoptosis of Gingival Cells and its Related Research Progress

作　　者：杨儒壮[1] 张瑜(综述)[2] 齐羲明(审校)[3] YANG Ru-zhuang;ZHANG Yu;QI Xi-ming(Department of Stomatology,Qinhuangdao First Hospital,Qinhuangdao 063000,Hebei,China;Department of Oncology,Qinhuangdao First Hospital,Qinhuangdao 063000,Hebei,China;Central Laboratory,Qinhuangdao First Hospital,Qinhuangdao 063000,Hebei,China)

机构地区：[1]秦皇岛市第一医院口腔科,河北秦皇岛063000 [2]秦皇岛市第一医院肿瘤科,河北秦皇岛063000 [3]秦皇岛市第一医院中心实验室,河北秦皇岛063000

出　　处：《中国美容医学》2020年第12期190-193,共4页Chinese Journal of Aesthetic Medicine

摘　　要：随着我国高血压患者的增多,钙离子通道阻滞剂越来越多地用于治疗高血压,然而服用钙离子通道阻滞剂后会发生牙龈组织增生。这种牙龈增生不仅影响患者牙龈的健康和美观,还干扰患者高血压的治疗,严重影响了患者的生活质量。因此,为防止钙离子通道阻滞剂介导的牙龈增生(Calcium-channel blockers induced gingival overgrowth,CIGO),对其机制的研究具有一定的临床意义,有研究表明这种增生与牙龈组织细胞的增殖和凋亡平衡被破坏有关,本文对钙离子通道阻滞剂介导牙龈组织细胞凋亡的相关文献进行综述,旨在为未来CIGO的发生机制研究中提供参考。With the increase of patients with hypertension in China,calcium channel blockers are more and more used to treat hypertension.However,gingival overgrowth will occur after taking calcium channel blockers.This kind of gingival overgrowth not only affects the health and beauty of patients'gums,but also interferes with the treatment of hypertension,and seriously affects the quality of life of patients.Therefore,in order to prevent the calcium channel blocker induced gingival overgrowth(CIGO),it is of clinical significance to study the mechanism of CIGO.Some studies have shown that this gingival overgrowth is related to the destruction of the balance between proliferation and apoptosis of gingival cells,In this paper,we reviewed the related literature of calcium channel blockers induced apoptosis of gingival cells,in order to provide a reference for the mechanism of CIGO in the future.

关 键 词：钙离子通道阻滞剂 牙龈增生 细胞凋亡 BCL-2基因 microRNAs 

分 类 号：R781.47[医药卫生—口腔医学]