基于医疗大数据的五运六气禀赋与糖尿病相关性研究  

Correlation Between Endowments of Wuyun Liuqi and Diabetes Mellitus Based on Medical Big Data

作　　者：王莉[1] 吴波[2] 郭良清[2] 陈晓燕[2] WANG Li;WU Bo;GUO Liangqing;CHEN Xiaoyan(Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Shandong Provincial Hospital of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学,山东济南250355 [2]山东省中医院,山东济南250014

出　　处：《山东中医药大学学报》2021年第1期29-38,共10页Journal of Shandong University of Traditional Chinese Medicine

基　　金：山东省自然科学基金项目(编号:ZR2019MH064);济南市临床医学科技创新计划项目(编号:201805079)。

摘　　要：目的:基于医疗大数据研究出生时对应的五运六气与后天患糖尿病的相关性。方法:病历资料来源于山东省中医院电子病历系统,收集2012年1月1日至2017年12月31日住院治疗的221556例临床病案,经过数据预处理清洗后保留136775个有效病例,其中诊断为糖尿病的患者16476例作为糖尿病组,1型糖尿病组128例,2型糖尿病组16190例,特殊类型糖尿病组49例,妊娠糖尿病组109例,同期不患糖尿病的住院患者120299例作为对照组。根据出生日期标注不同五运六气类别,如岁运、司天,采用Pearson卡方检验和经年龄、性别校正后的二元Logistics回归进行统计分析,研究五运六气禀赋与糖尿病的相关性。结果:出生时对应的岁运差异在糖尿病组与对照组有统计学意义(P<0.01),出生时对应的岁运差异在2型糖尿病组与对照组有统计学意义(P<0.01);出生时对应的岁运为土运的人群患糖尿病的可能性较高(OR=1.08,95%CI为1.02~1.14,P<0.01),在4个亚组中,出生时对应的岁运为土运的人群患2型糖尿病的可能性较高(OR=1.08,95%CI为1.03~1.14,P<0.01),其余亚组与出生时岁运没有相关性(P>0.01)。出生时对应的司天差异在糖尿病组与对照组有统计学意义(P<0.01),出生时对应的司天差异在2型糖尿病组与对照组的分布有统计学意义(P<0.01);糖尿病组及其亚组与出生时司天均没有相关性(P>0.01)。结论:五运六气禀赋与糖尿病患病具有相关性,出生在岁运为土运的人群更容易患糖尿病,2型糖尿病病机与脾脏虚弱有密切关系。Objective:To study the correlation between the Wuyun Liuqi at birth and the acquired diabetes mellitus based on medical big data.Methods:The medical record data comes from total 221556 hospitalized clinical cases in the electronic medical records system of Shandong Provincial Hospital of Traditional Chinese Medicine,from January 1,2012 to December 31,2017.After data preprocessing and cleaning,total 136775 effective cases were retained,among which 16476 patients diagnosed with diabetes were regarded as the diabetes group,total 128 patients in the type 1 diabetes group,16190 patients in the type 2 diabetes group,49 patients in the special type diabetes group,109 patients in the gestational diabetes group,and 120299 hospitalized patients without diabetes during the same period were used as the control group.Different categories of Wuyun Liuqi were marked according to the date of birth,such as Suiyun,Sitian.Pearson’s chi-square test and binary Logistics regression adjusted for age and gender were used for statistical analysis to study the correlation between endowments of Wuyun Liuqi and diabetes mellitus.Results:There were statistical significances in the distribution of Suiyun between the diabetes group and the control group(P<0.01),and there were statistical significances in the distribution of Suiyun between the type 2 diabetes group and the control group(P<0.01).The population whose birth year corresponded to Tuyun was more likely to develop diabetes(OR=1.08,95%CI:1.02~1.14,P<0.01),among the four subgroups,the population whose birth year corresponded to Tuyun was more likely to develop type 2 diabetes(OR=1.08,95%CI:1.03~1.14,P<0.01),the rest subgroups had no correlation with Suiyun at birth(P>0.01).There were statistical significances in the distribution of Sitian at birth between the diabetes group and the control group(P<0.01),and there were statistical significances in the distribution of Sitian at birth between the type 2 diabetes group and the control group(P<0.01).There was no correlation between diabete

关 键 词：五运六气 出生时间 2型糖尿病 数据挖掘 岁运 司天 土运 脾脏虚弱 

分 类 号：R226[医药卫生—中医基础理论] R259.871[医药卫生—中医学]