Clinical observation of mineralized collagen bone grafting after curettage of benign bone tumors  

作　　者：Chong Gao Zhi-Ye Qiu Jian-Wen Hou Wei Tian Jian-Ming Kou Xi Wang 

机构地区：[1]Department of Orthopedics,The Second People’s Hospital of Lianyungang,No.41 Hailiandong Road,Xinpu District,Lianyungang,Jiangsu 222006,China [2]School of Materials Science and Engineering,Tsinghua University,Haidian District,Beijing 100085,China [3]R&D Department,Allgens Medical Science Corporation,No.26 Yongwangxi Road,Daxing District,Beijing 102629,China

出　　处：《Regenerative Biomaterials》2020年第6期567-575,共9页再生生物材料（英文版）

基　　金：part supported by Research Fund for Jiangsu Provincial Commission of Health and Family Planning(H201559);Science and Technology Development Project of Lianyungang City(SH1412);the National Key R&D Program of China(2020YFC1107600).

摘　　要：Curettage of benign bone tumor is a common cause for bone defect.For such bone defect repair,autogenous bone,allogeneic bone and traditional artificial bone graft substitutes have many disadvantages.In recent years,a biomimetic mineralized collagen(MC)with similar composition and microstructures to the natural bone matrix was developed and used for treating various bone defects.In this work,a retrospective study analyzed clinical outcomes of patients treated with curettage of benign bone tumors and bone grafting with MC,in comparison to another group treated with the same surgical method and autogenous bone.Lane-Sandhu X-ray score of the autogenous bone group was superior to the MC group at 1 month after the operation,but the two groups had no statistical difference at 6 and 12 months.The MC group was better in Musculoskeletal Tumor Society scoring at 1 and 6 months after the operation,and the two groups had no statistical difference at 12 month.Therefore,the MC performed not as good as autogenous bone in early stage of bone healing but achieved comparable outcomes in long-term follow-ups.Moreover,the MC has advantages in function recovery and avoided potential complications induced by harvesting autogenous bone.

关 键 词：benign bone tumor mineralized collagen autogenous bone bone grafting 

分 类 号：R738.1[医药卫生—肿瘤]