多参数MRI对子宫肉瘤与良性子宫肌瘤的鉴别诊断价值及与肿瘤细胞恶性程度的关系  

The Value of Multi-parameter MRI in the Differential Diagnosis of Uterine Sarcoma and Benign Uterine Fibroids and the Relationship with the Malignant Degree of Tumor Cells

作　　者：卜岛 韩茜茜[1] BU Dao;HAN Qianqian(Department of Radiology,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100026,P.R.China)

机构地区：[1]首都医科大学附属北京妇产医院放射科,北京100026

出　　处：《影像科学与光化学》2021年第1期81-86,共6页Imaging Science and Photochemistry

摘　　要：本文选取子宫肉瘤(US)患者103例作为观察组,另选取同期良性子宫肌瘤患者103例作为对照组,探究多参数MRI对US与良性子宫肌瘤的鉴别诊断效果及与肿瘤细胞恶性程度的关系。结果发现,观察组达峰时间(TTP)、扩散系数(ADC)低于对照组;随临床分期增加,TTP、ADC呈下降趋势,TopoⅡα、AgNOR、PDGFα、Matriptase mRNA相对表达量呈升高趋势,TTP、ADC与TopoⅡα、AgNOR、PDGFα、Matriptase mRNA相对表达量呈负相关,且TTP、ADC联合鉴别诊断US和良性子宫肌瘤的AUC值最大,提示US与良性子宫肌瘤MRI参数存在显著差异,且TTP、ADC值与增殖分子、侵袭分子活性直接相关,可为临床鉴别诊断提供数据支持。In this research,103 uterine sarcoma(US)patients were selected as the observation group,and 103 patients with benign uterine fibroids were selected as the control group.The value of MRI multi-parameters in the differential diagnosis of US and benign uterine fibroids were explored,as well as the relationship between the MRI parameters and the malignancy of tumor cells.The time to peak(TTP)and apparent diffusion coefficient(ADC)of the observation group were lower than those of the control group.TTP and ADC showed a downward trend with the increase of clinical stage,while the relative expression of TopoⅡα,AgNOR,PDGFα,and Matriptase mRNA showed an increasing trend with the increase of clinical stage.TP,ADC were negatively correlated with TopoⅡα,AgNOR,PDGFαand Matriptase mRNA relative expression.And the combined AUC value of TTP and ADC was the largest in differential diagnosis of US and benign uterine fibroids.These results indicated that there were significant differences in MRI parameters between US and benign uterine fibroids.TTP and ADC values are directly related to the activities of proliferation molecules and invasion molecules,which can provide data support for clinical differential diagnosis.

关 键 词：MRI 子宫肉瘤 子宫肌瘤 肿瘤细胞 MATRIPTASE Topoip 增殖分子 

分 类 号：R445.2[医药卫生—影像医学与核医学] R737.33[医药卫生—诊断学]