This study was supported by Cancer Institute Grant R01 CA 123223(to MDJ and CYL);Grant(MAB-108-079)from the Ministry of Defense Medical Affairs Bureau;Grants(CMNDMC10705,CMNDMC10813)from Chi-Mei Medical Center(to J.-K.Wang);Grant(TSGH-E-109213-003)from Tri-Service General Hospital(to Y.-Y.Wu);Grants(108-2311-B-016-001-,109-2320-B-016-004-)from Ministry of Science and Technology(to Y.-L.Chiu).
The integral membrane,Kunitz-type serine protease inhibitors HAI-1 and HAI-2,can suppress the proteolytic activity of the type 2 transmembrane serine protease matriptase with high specificity and potency.High levels o...