中国大陆免疫抑制剂相关型Kaposi肉瘤(1995—2020年)回顾性分析  

A retrospective analysis of immunosuppressive-related Kaposi sarcoma in China's Mainland(1995—2020)

作　　者：杨娟 鲁莎[2] 张静[2] 李希清[2] YANG Juan;LU Sha;ZHANG Jing;LI Xi-qing(Department of Dermatology, Zengcheng District People′s Hospital of Guangzhou, Guangzhou 511300, China;Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China)

机构地区：[1]广州市增城区人民医院皮肤科,广东广州511300 [2]中山大学孙逸仙纪念医院皮肤科,广东广州510120

出　　处：《皮肤性病诊疗学杂志》2020年第6期387-391,共5页Journal of Diagnosis and Therapy on Dermato-venereology

摘　　要：目的:了解中国大陆地区近25年免疫抑制剂相关型Kaposi肉瘤的临床特征和诊治现状。方法:通过中国知网、万方、维普和Pubmed检索1995—2020年中国大陆地区免疫抑制剂相关型Kaposi肉瘤相关文献,进行数据分析和总结。结果:共纳入文献40篇,共计42例患者。患者平均年龄47.4岁;男女患病比例3.67∶1;多发生在肾移植术后使用一种或多种免疫抑制剂/糖皮质激素;于用药后2~3个月或1~2年发病。较多累及全身皮肤,其中下肢多见,也可累及内脏器官或淋巴结。治疗以减少或停用或更换免疫抑制剂/糖皮质激素为主,必要时可联合其他治疗方案。结论:在临床上长期使用免疫抑制剂或激素后应警惕Kaposi肉瘤的发生,减少或停用或更换免疫抑制剂/糖皮质激素后多预后良好。Objective:To study the clinical features and treatment of immunosuppressive-related Kaposi sarcoma in China's Mainland.Methods:Literature articles on immunosuppressive-related Kaposi sarcoma in the Chinese mainland from 1995 to 2020 were searched through CNKI,Wangfang,Weipu and Pubmed databases and systematically analyzed.Results:A total of 42 patients from 40 cases report were included in the review.The mean age was 47.4 years and the male-to-female ratio was 3.67∶1.Compared with other patients,a higher incidence of immunosuppressive-related Kaposi sarcoma was reported in patients with renal transplant and patients treated with one or more immunosuppressants/glucocorticoids.Most cases developed the immunosuppressive-related kaposi sarcoma within 2~3 months or 1~2 years after treatment with immunosuppressive drugs.The lesions were frequently reported in cutaneous,especially in the lower limbs,and less frequently in lymph nodes and visceral organs.The most common treatments for immunosuppressive-related Kaposi sarcoma included discontinuing of immunosuppressive drugs,reducing the amount of immunosuppressive drugs,replacing immunosuppressive drugs/glucocorticoids with other drugs or combined all these therapy.Conclusion:Our results indicate that long-term use of immunosuppressive agents or glucocorticoids can increase the occurrence of the immunosuppressive-related Kaposi sarcoma,and discontinuing or reducing these immunosuppressive drugs with other drugs can improve the prognosis of these patients.

关 键 词：免疫抑制剂 KAPOSI肉瘤 肾移植术后 治疗 

分 类 号：R739.5[医药卫生—肿瘤]