静脉旁路移植疾病动物模型的建立及应用进展  

Establishment and application of animal models of venous bridge disease after coronary artery bypass grafting

作　　者：杨仁从 杨丰华[2] 李小辉[1] 李相念 李文华 廖胜杰 张晓慎 YANG Rencong;YANG Fenghua;LI Xiaohui;LI Xiangnian;LI Wenhua;LIAO Shengjie;ZHANG Xiaoshen(Department of Cardiovascular Surgery,the First Affiliated Hospital of Jinan University,Guangzhou 510630,China;Guangdong Provincial Key Laboratory for Laboratory Animals,Guangdong Laboratory Animals Monitoring Institute,Guangzhou 510633)

机构地区：[1]暨南大学附属第一医院心血管外科,广州510630 [2]广东省实验动物监测所/广东省实验动物重点实验室,广州510633

出　　处：《中国比较医学杂志》2020年第12期113-119,共7页Chinese Journal of Comparative Medicine

基　　金：广东省科技计划项目(2017A020215076)。

摘　　要：心血管疾病是全球疾病负担之首,其中缺血性心脏病严重危害着人们身心健康,且发病率和死亡率仍在增加。冠状动脉旁路移植术是治疗缺血性心脏病的方法之一,它有效得重建了心脏血运,但是面临着静脉移植血管远期通畅率不足的问题。因此,稳定的动物模型能够为研究解决静脉旁路移植疾病提供工具。本文总结了静脉旁路移植病动物模型的建立及应用,为建立疾病动物模型研究提供新思路。Cardiovascular diseases constitute the largest burden to health worldwide.Ischemic heart disease seriously harms the physical and mental health of sufferers and its morbidity and mortality continue to increase.Coronary artery bypass grafting is a treatment for ischemic heart disease that can effectively rebuild the blood flow of the heart,but it has the problem of an insufficient long-term patency rate for venous grafts.Stable animal models can provide tools to investigate venous bypass graft diseases.This article summarizes the establishment and application of animal models of venous bypass graft disease to stimulate new ideas for research.

关 键 词：冠状动脉旁路移植术 静脉移植物 再狭窄 动物模型 基因治疗 

分 类 号：R-33[医药卫生]